Proton nuclear magnetic resonance imaging of regionally ischemic canine hearts: effects of paramagnetic proton signal enhancement

Conference · Thu Jul 01 04:00:00 EDT 1982 · Radiology; (United States)

OSTI ID:5030258

Brady, T J; Goldman, M R; Pykett, I L; Buonanno, F S; Kistler, J P; Newhouse, J H; Burt, C T; Hinshaw, W S; Pohost, G M

In a study to evaluate the potential of proton nuclear magnetic resonance (NMR) imaging with and without manganese contrast enhancement for detecting acute myocardial infarction, 12 dogs underwent 90-minute occlusion of the left circumflex coronary artery. Transverse-section NMR images of the excised, nonbeating heart were obtained at 1-cm intervals using the steady-state-free-precession (SSFP) technique. All NMR images revealed detailed structure of the heart. The three hearts without manganese showed no difference in intensity between the normal and the ischemic posterior regions, whereas those with manganese demonstrated a clearly demarcated zone of reduced signal intensity consistent with the ischemic zone. It is concluded that high-resolution tomograms of the excised canine myocardium can be obtained using proton NMR imaging. With the SSFP imaging technique, proton signal enhancement with manganese infusion is necessary to differentiate between ischemic and nonischemic myocardium after 90 minutes of coronary occlusion.

• Research Organization: Massachusetts General Hospital, Boston
• OSTI ID: 5030258
• Conference Information: Journal Name: Radiology; (United States) Journal Volume: 144:2
• Country of Publication: United States
• Language: English

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62 RADIOLOGY AND NUCLEAR MEDICINE
BETA DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BODY
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
CHLORIDES
CHLORINE COMPOUNDS
COMPARATIVE EVALUATIONS
CONTRAST MEDIA
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DISEASES
ELECTRON CAPTURE RADIOISOTOPES
HALIDES
HALOGEN COMPOUNDS
HEART
HEAVY NUCLEI
ISCHEMIA
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAGNETIC RESONANCE
MANGANESE CHLORIDES
MANGANESE COMPOUNDS
MANGANESE HALIDES
MUSCLES
MYOCARDIAL INFARCTION
MYOCARDIUM
NUCLEAR MAGNETIC RESONANCE
NUCLEI
ODD-EVEN NUCLEI
ORGANS
RADIOISOTOPE SCANNING
RADIOISOTOPES
RESONANCE
SECONDS LIVING RADIOISOTOPES
THALLIUM 201
THALLIUM CHLORIDES
THALLIUM COMPOUNDS
THALLIUM ISOTOPES
TRANSITION ELEMENT COMPOUNDS
VASCULAR DISEASES