Evaluation of early myocardial ischemia with /sup 201/Tl in the pig

Conference · Tue Nov 01 04:00:00 EST 1977 · Radiology; (United States)

OSTI ID:5335113

Schwartz, J S; Ponto, R A; Forstrom, L A; Carlyle, P F; McGregor, L R; Cohn, J N; Loken, M K

Thallium-201 was found to be a reliable agent for detecting decreased myocardial perfusion in domestic pigs 1 to 4 hours after acute coronary occlusion. Substantial variation in myocardial-to-liver count ratios and diagnostic quality was observed in serial images performed in 3 normal pigs, although areas of 1 to 4 hours-old myocardial ischemia produced by acute circumflex coronary artery ligation in 6 pigs could be reliably detected by in vivo /sup 201/Tl imaging. After intravenous /sup 201/Tl administration, the animals were sacrificed and sections of normal and ischemic myocardium were counted in a scintillation well counter. The activity in the ischemic area in pigs averaged 12% of the activity in the normal area, and varied over a narrow range; in dogs the activity averaged 62% of normal, and varied over a wide range. The pig was a more consistent model than the dog.

• Research Organization: Univ. of Minnesota Medical School, Minneapolis
• OSTI ID: 5335113
• Conference Information: Journal Name: Radiology; (United States) Journal Volume: 125:2
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ANEMIAS
ANIMALS
BETA DECAY RADIOISOTOPES
BODY
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DISEASES
DOGS
DOMESTIC ANIMALS
ELECTRON CAPTURE RADIOISOTOPES
HEART
HEAVY NUCLEI
HEMIC DISEASES
ISCHEMIA
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
MUSCLES
MYOCARDIUM
NUCLEI
ODD-EVEN NUCLEI
ORGANS
RADIOISOTOPE SCANNING
RADIOISOTOPES
SCINTISCANNING
SECONDS LIVING RADIOISOTOPES
SWINE
SYMPTOMS
THALLIUM 201
THALLIUM ISOTOPES
VERTEBRATES