Early redistribution of thallium-201 after temporary ischemia

Journal Article · Tue Jan 31 23:00:00 EST 1978 · Circulation; (United States)

DOI:https://doi.org/10.1161/01.CIR.57.2.332· OSTI ID:5732551

Schwartz, J S; Ponto, R; Carlyle, P; Forstrom, L; Cohn, J N

To define the time course of redistribution of /sup 201/Tl, ischemia was induced in seven pigs by temporary occlusion of the circumflex coronary artery. After 1-1/2 min of occlusion /sup 201/Tl and labeled microspheres were injected into the left atrium. Flow was re-established 4 min after occlusion. Prior to reflow, the relative activities of /sup 201/Tl and microspheres in the ischemic area were similar, but as early as 5 min after reflow the relative /sup 201/Tl activity was considerably higher than the relative microsphere activity and from 15 to 105 min after reflow, relative /sup 201/Tl activity (average 69% of that in normal myocardium) continued to be higher than relative microsphere activity (average 6% of normal). Myocardial arteriovenous differences for /sup 201/Tl were followed sequentially after /sup 201/Tl injection in normal dogs and in dogs with temporary coronary occlusions. The results suggested both loss of /sup 201/Tl from normal myocardium beginning 10 min after /sup 201/Tl injection and increased extraction of /sup 201/Tl from the blood pool immediately after release of a transient occlusion. Redistribution of /sup 201/Tl therefore begins very soon after relief of myocardial ischemia and even a short delay in initiating myocardial imaging may decrease the sensitivity of the technique for detecting transient ischemia.

• Research Organization: Univ. of Minnesota, Minneapolis
• OSTI ID: 5732551
• Journal Information: Circulation; (United States), Journal Name: Circulation; (United States) Vol. 57:2; ISSN CIRCA
• Country of Publication: United States
• Language: English

Related Subjects

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59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANEMIAS
ANIMALS
BETA DECAY RADIOISOTOPES
BIOLOGICAL LOCALIZATION
BLOOD-PLASMA CLEARANCE
BODY
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
CLEARANCE
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DISEASES
DOGS
DOMESTIC ANIMALS
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
HEART
HEAVY NUCLEI
HEMIC DISEASES
ISCHEMIA
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
MAMMALS
MUSCLES
MYOCARDIUM
NUCLEI
ODD-EVEN NUCLEI
ORGANS
RADIOACTIVE MATERIALS
RADIOISOTOPE SCANNING
RADIOISOTOPES
RADIONUCLIDE KINETICS
RADIOPHARMACEUTICALS
SCINTISCANNING
SECONDS LIVING RADIOISOTOPES
SWINE
SYMPTOMS
THALLIUM 201
THALLIUM ISOTOPES
TIME DEPENDENCE
VERTEBRATES