Differentiation of transiently ischemic from infarcted myocardium by serial imaging after a single dose of /sup 201/Tl. [Dogs]

Journal Article · Mon Jan 31 23:00:00 EST 1977 · Circulation; (United States)

DOI:https://doi.org/10.1161/01.CIR.55.2.294· OSTI ID:7110227

Pohost, G M; Zir, L M; Moore, R H; McKusick, K A; Guiney, T E; Beller, G A

Myocardial /sup 201/Tl uptake and regional blood flow by the microsphere technique were determined in anesthetized dogs undergoing either 20 min of coronary occlusion and 100 min of reperfusion (N = 10) or 120 min of occlusion (N = 4). In both groups, /sup 201/Tl was injected intravenously after 10 min of occlusion. In transiently occluded dogs, regional flow at the time of /sup 201/Tl administration was reduced to 8 +- 3 percent of normal flow in endocardial layers of the central ischemic zone. After 100 min of reperfusion, flow values were not significantly different from normal. /sup 201/Tl activity after reperfusion rose to 56 +- 5 percent of normal, demonstrating that redistribution of the radionuclide occurred during the reflow period. In animals with persistent occlusion, there was a significant relationship between /sup 201/Tl uptake and flow (r = 0.95) and no evidence of redistribution of /sup 201/Tl during the two hour occlusion period. In another five dogs receiving /sup 201/Tl, serial gamma camera images obtained during reperfusion showed increasing uptake of the tracer in apical defects which returned to normal by 4 hours of reflow. Thirteen patients with stable angina received 2 mCi of /sup 201/Tl intravenously at peak exercise, and multiple gamma camera images obtained serially. All demonstrated zones of diminished /sup 201/Tl uptake 10 min after exercise. Defects which disappeared within 1-6 hours postexercise corresponded to areas supplied by coronary arteries with significant stenoses. Persistent defects were present in regions of old myocardial infarction. Six patients with acute myocardial infarction demonstrated /sup 201/Tl myocardial defects which showed no significant change over 6 hours. Redistribution of /sup 201/Tl into ischemic myocardium was demonstrated during transient coronary occlusion in dogs and after exercise stress in man.

• Research Organization: Harvard Medical School, Boston
• OSTI ID: 7110227
• Journal Information: Circulation; (United States), Journal Name: Circulation; (United States) Vol. 55:2; ISSN CIRCA
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ANEMIAS
ANIMALS
BETA DECAY RADIOISOTOPES
BLOOD FLOW
BODY
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DISEASES
DOGS
ELECTRON CAPTURE RADIOISOTOPES
EXERCISE
HEART
HEAVY NUCLEI
HEMIC DISEASES
IMAGES
ISCHEMIA
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
MICROSPHERES
MUSCLES
MYOCARDIAL INFARCTION
MYOCARDIUM
NUCLEI
ODD-EVEN NUCLEI
ORGANS
PATIENTS
RADIOISOTOPE SCANNING
RADIOISOTOPES
SCINTISCANNING
SECONDS LIVING RADIOISOTOPES
SYMPTOMS
THALLIUM 201
THALLIUM ISOTOPES
VERTEBRATES