Correlation of chromosome patterns in leukemic cells of patients with exposure to chemicals and/or radiation
Technical Report
·
OSTI ID:6582565
Progress made in understanding the molecular genetics of leukemia is described. We have had remarkable success in applying the new techniques of using nonradiolabeled DNA probes to identify chromosome abnormalities more precisely. We have continued to update our series of patients who have treatment related acute myeloid leukemia (AML) and myelodysplasia (MDS). We have identified malignant cells in five adult patients with MDS or AML. Also discussed is mapping DNA probes to chromosome 5.5 refs., 5 figs., 5 tabs.
- Research Organization:
- Chicago Univ., IL (USA)
- Sponsoring Organization:
- DOE/ER
- DOE Contract Number:
- FG02-86ER60408
- OSTI ID:
- 6582565
- Report Number(s):
- DOE/ER/60408-2; ON: DE90017603
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550200 -- Biochemistry
550400* -- Genetics
550900 -- Pathology
59 BASIC BIOLOGICAL SCIENCES
ANIMAL CELLS
ANIMALS
BIOLOGICAL MARKERS
CARCINOGENESIS
CHROMOSOMAL ABERRATIONS
CHROMOSOMES
CORRELATIONS
DISEASES
DNA
DNA HYBRIDIZATION
DOCUMENT TYPES
ENZYMES
EUMYCOTA
FUNGI
GENE RECOMBINATION
GENETIC MAPPING
HEMIC DISEASES
HETEROCHROMOSOMES
HUMAN CHROMOSOME 5
HYBRIDIZATION
IMMUNE SYSTEM DISEASES
LEUKEMIA
LEUKEMOGENESIS
MAMMALS
MAN
MAPPING
MICROORGANISMS
MOLECULAR BIOLOGY
MUTATIONS
NEOPLASMS
NUCLEIC ACIDS
ORGANIC COMPOUNDS
PATHOGENESIS
PHOSPHORUS-GROUP TRANSFERASES
PHOSPHOTRANSFERASES
PLANTS
PRIMATES
PROBES
PROGRESS REPORT
THERAPY
TRANSFERASES
TUMOR CELLS
VERTEBRATES
YEASTS
550400* -- Genetics
550900 -- Pathology
59 BASIC BIOLOGICAL SCIENCES
ANIMAL CELLS
ANIMALS
BIOLOGICAL MARKERS
CARCINOGENESIS
CHROMOSOMAL ABERRATIONS
CHROMOSOMES
CORRELATIONS
DISEASES
DNA
DNA HYBRIDIZATION
DOCUMENT TYPES
ENZYMES
EUMYCOTA
FUNGI
GENE RECOMBINATION
GENETIC MAPPING
HEMIC DISEASES
HETEROCHROMOSOMES
HUMAN CHROMOSOME 5
HYBRIDIZATION
IMMUNE SYSTEM DISEASES
LEUKEMIA
LEUKEMOGENESIS
MAMMALS
MAN
MAPPING
MICROORGANISMS
MOLECULAR BIOLOGY
MUTATIONS
NEOPLASMS
NUCLEIC ACIDS
ORGANIC COMPOUNDS
PATHOGENESIS
PHOSPHORUS-GROUP TRANSFERASES
PHOSPHOTRANSFERASES
PLANTS
PRIMATES
PROBES
PROGRESS REPORT
THERAPY
TRANSFERASES
TUMOR CELLS
VERTEBRATES
YEASTS