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Time dependence of chromosomal aberrations induced in human and monkey lymphocytes by acute and fractionated exposure to /sup 60/Co

Journal Article · · Radiat. Res.; (United States)
DOI:https://doi.org/10.2307/3577462· OSTI ID:6579858
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Changes in the numbers of peripheral lymphocytes with chromosome aberrations were observed in cynomolgus monkeys after fractionated or acute /sup 60/Co irradiation at the same total doses. Immediately after irradiation, the yield of dicentrics decreased when the dose was fractionated but remained constant for 20 to 80 days, depending on the dose, when irradiation was acute. Lymphopenia was greater than expected when the dose was fractionated. The kinetics of the loss of chromosome aberrations and the changes in peripheral lymphocyte count occurring in monkeys after acute irradiation were compared to those observed in accidentally irradiated men.
Research Organization:
Commissariat a l'energie atomique, IPSN/DPS/SPE, Fontenay aux Roses (France)
OSTI ID:
6579858
Journal Information:
Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 116:2; ISSN RAREA
Country of Publication:
United States
Language:
English

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Related Subjects

560151 -- Radiation Effects on Animals-- Man
560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACUTE EXPOSURE
ACUTE IRRADIATION
ANIMAL CELLS
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL RADIATION EFFECTS
BLOOD
BLOOD CELLS
BODY FLUIDS
CHROMOSOMAL ABERRATIONS
COBALT 60
COBALT ISOTOPES
CONNECTIVE TISSUE CELLS
DOSES
EXTERNAL IRRADIATION
FRACTIONATED IRRADIATION
GENETIC EFFECTS
GENETIC RADIATION EFFECTS
IN VITRO
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IRRADIATION
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LEUKOCYTES
LYMPHOCYTES
MAMMALS
MAN
MATERIALS
MINUTES LIVING RADIOISOTOPES
MONKEYS
MUTATIONS
NUCLEI
ODD-ODD NUCLEI
PRIMATES
RADIATION DOSES
RADIATION EFFECTS
RADIOINDUCTION
RADIOISOTOPES
SOMATIC CELLS
TIME DEPENDENCE
VERTEBRATES
WHOLE-BODY IRRADIATION
YEARS LIVING RADIOISOTOPES