Chromosome aberrations in the peripheral lymphocytes induced by brachytherapy and external cobalt teletherapy

Journal Article · Sat Jun 01 04:00:00 EDT 1985 · Int. J. Radiat. Oncol., Biol. Phys.; (United States)

DOI:https://doi.org/10.1016/0360-3016(85)90054-9· OSTI ID:5355382

Matsubara, S; Horiuchi, J; Okuyama, T; Takeda, M; Shibuya, H; Suzuki, S; Kishi, K

In the present study, the induction efficiencies of chromosome aberrations were analyzed in patients receiving various modalities of interstitial radiotherapy with small radiation sources in the oral cavity area and compared with those in patients treated with external telecobalt irradiation in the thoracic region. Further, as a local nonstochastic effect, the acute mucosal reaction was investigated. The mucosal reaction in the area treated by brachytherapy reached a maximum at two to three weeks after the implantation. The frequencies of dicentrics plus rings of peripheral lymphocytes, on the other hand, revealed rapid increases and approached plateau levels as early as two days after the implantation. The radiation doses used in the patients who received brachytherapy or a single external irradiation were found to exert the same effects on the chromosome aberration induction. However, even in the case of brachytherapy in which whole-body side effects were believed to be trivial, the pheripheral lymphocyte count was temporarily reduced to one half or less of the preirradiation level. An equivalent whole-body dose of 50 cGy was obtained from the frequencies of dicentrics and rings.

• Research Organization: Tokyo Medical and Dental Univ., Japan
• OSTI ID: 5355382
• Journal Information: Int. J. Radiat. Oncol., Biol. Phys.; (United States), Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Vol. 11:6; ISSN IOBPD
• Country of Publication: United States
• Language: English

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62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKALINE EARTH ISOTOPES
ALPHA DECAY RADIOISOTOPES
ANIMAL CELLS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL RADIATION EFFECTS
BLOOD
BLOOD CELLS
BODY
BODY AREAS
BODY FLUIDS
CHEST
CHROMOSOMAL ABERRATIONS
CHROMOSOMES
COBALT 60
COBALT ISOTOPES
CONNECTIVE TISSUE CELLS
DATA
DAYS LIVING RADIOISOTOPES
DICENTRIC CHROMOSOMES
DIGESTIVE SYSTEM
ELECTROMAGNETIC RADIATION
ELECTRON CAPTURE RADIOISOTOPES
EVEN-EVEN NUCLEI
EXPERIMENTAL DATA
GAMMA RADIATION
GOLD 198
GOLD ISOTOPES
HEAVY NUCLEI
IMPLANTS
INFORMATION
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IONIZING RADIATIONS
IRIDIUM 192
IRIDIUM ISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LEUKOCYTES
LYMPHOCYTES
MATERIALS
MEDICINE
MEMBRANES
MINUTES LIVING RADIOISOTOPES
MUCOUS MEMBRANES
MUTATIONS
NUCLEAR MEDICINE
NUCLEI
NUMERICAL DATA
ODD-ODD NUCLEI
ORAL CAVITY
RADIATION EFFECTS
RADIATION SOURCE IMPLANTS
RADIATION SOURCES
RADIATIONS
RADIOINDUCTION
RADIOISOTOPES
RADIOLOGY
RADIOTHERAPY
RADIUM 226
RADIUM ISOTOPES
SIDE EFFECTS
SOMATIC CELLS
THERAPY
YEARS LIVING RADIOISOTOPES