Changes in frequency of chromosome aberrations of human peripheral lymphocytes during the course of fractionated radiotherapy in cervical cancer, emphasis on the lymphocyte kinetics (in Japanese)
The relationship between numbers of radiation therapy and frequency of chromosome aberrations was investigated by studying chromosomes in the peripheral lymphocytes during the course of radiotherapy in patients with uterine cancer. Heteroploidy cells rapidly increased after the 1st or the 2nd irradiation, and after then they were constant. There was no evident relationship between the number of 4-fold somatic cells and that of the cells with chromatid-type aberration. The number of the cells with unstable chromosome aberrations increased linearly until the 5th irradiation. However, the number was constant between the 6th irradiation and the 10th irradiation, and then it showed a tendency to increase again. In addition, the distribution in the number of dicentrics per cell was well similar to that of poisson. The number of peripheral lymphocytes began to decrease rapidly after the 7th irradiation. After then, it was constant, and again decreased with numbers of irradiation. From these results, it is hypothesized that lymphocytes in the peripheral blood and general lymphatic histiocytes are interchanged at intervals of about one hour. (JA)
- Research Organization:
- Kyoto Univ.
- NSA Number:
- NSA-29-007990
- OSTI ID:
- 4368047
- Journal Information:
- Nippon Sanka Fujinka Gakkai Zasshi, v. 25, no. 1, pp. 10-18, Other Information: Orig. Receipt Date: 30-JUN-74; Bib. Info. Source: JA (JA)
- Country of Publication:
- Japan
- Language:
- Japanese
Similar Records
Differential sensitivity to x ray of chromosomes of blood T-lymphocytes and B- and T-cell lines
Time dependence of chromosomal aberrations induced in human and monkey lymphocytes by acute and fractionated exposure to /sup 60/Co