Effects of contrast medium on radiation-induced chromosome aberrations

Journal Article · Thu Jul 01 04:00:00 EDT 1982 · Radiology; (United States)

DOI:https://doi.org/10.1148/radiology.144.2.7089283· OSTI ID:7066255

Matsubara, S; Suzuki, S; Suzuki, H; Kuwabara, Y; Okano, T

The effects of contrast material (meglumine iothalamate) on radiation-induced chromosome aberrations were investigated in studies on the lymphocytes of patients who had undergone diagnostic radiography and in in vitro experiments with diagnostic x rays and /sup 60/Co gamma rays. Chromosome and chromatid aberrations were found to increase significantly with increasing concentrations of contrast material that were added at irradiation. However, the aberrations were not associated with elevation of the ratio of dicentric and ring chromosomes to the number of cells with unstable chromosome aberrations at the first mitosis. Lymphocytes irradiated in the absence of contrast material did not show an increase in chromosome-type aberrations when the agent was given in increasing concentrations during subsequent incubation, but there were greater numbers of chromatid gaps and breaks. When lymphocytes were exposed to 400 R (103.2 mC/kg) of /sup 60/Co gamma rays, the presence of contrast agent did not increase the yield of dicentric and ring chromosomes, but induced a marked delay in cell proliferation, especially in lymphocytes with more heavily damaged chromosomes. In additional examination, the contrast agent itself induced sister chromatid exchanges in lymphocytes.

• Research Organization: Department of Radiology, Tokyo Medical and Dental University, Japan
• OSTI ID: 7066255
• Journal Information: Radiology; (United States), Journal Name: Radiology; (United States) Vol. 144:2; ISSN RADLA
• Country of Publication: United States
• Language: English

Related Subjects

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560151* -- Radiation Effects on Animals-- Man
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL RADIATION EFFECTS
BIOMEDICAL RADIOGRAPHY
BLOOD
BLOOD CELLS
BODY FLUIDS
CHROMOSOMAL ABERRATIONS
CHROMOSOMES
COBALT 60
COBALT ISOTOPES
CONNECTIVE TISSUE CELLS
CONTRAST MEDIA
DIAGNOSTIC TECHNIQUES
DOSE-RESPONSE RELATIONSHIPS
ELECTROMAGNETIC RADIATION
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IONIZING RADIATIONS
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LEUKOCYTES
LYMPHOCYTES
MATERIALS
MEDICINE
MINUTES LIVING RADIOISOTOPES
MUTATIONS
NUCLEAR MEDICINE
NUCLEI
ODD-ODD NUCLEI
PATIENTS
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
RADIOISOTOPES
RADIOLOGY
RADIOSENSITIVITY EFFECTS
SIDE EFFECTS
SOMATIC CELLS
X RADIATION
YEARS LIVING RADIOISOTOPES