In vitro studies on the radioresistance of oxic and hypoxic cells in the presence of both radioprotective and radiosensitizing drugs. [x rays; CHO cells; cysteine; Ro-07-0582(1-2-hydroxy-3-methoxypropyl-2-nitroimidazole)]

Journal Article · Fri Sep 01 00:00:00 EDT 1978 · Radiat. Res.; (United States)

DOI:https://doi.org/10.2307/3574843· OSTI ID:6572605

Yuhas, J M; Li, A P

In vitro studies, involving CHO monolayers, have demonstrated that the oxygenation status of the cells determines whether radioprotection or radiosensitization will be observed when both Ro-07-0582 (6 mM) and cysteine (8 mM) are present in the medium. This combination sensitizes hypoxic cells yet protects well-oxygenated ones. A comparison of individual drug effects on radiation resistance with those of the combination indicates that the latter can yield a larger therapeutic gain than either alone through reduction of drug toxicity and/or by improving relative tumor response.

• Research Organization: Univ. of New Mexico, Albuquerque
• OSTI ID: 6572605
• Journal Information: Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 75:3; ISSN RAREA
• Country of Publication: United States
• Language: English

Related Subjects

560121* -- Radiation Effects on Cells-- External Source-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINO ACIDS
ANIMAL CELLS
ANIMALS
ANOXIA
AZOLES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
CARBOXYLIC ACIDS
CELL CULTURES
COMPARATIVE EVALUATIONS
CRYOGENIC FLUIDS
CYSTEINE
DRUGS
ELECTROMAGNETIC RADIATION
ELEMENTS
FLUIDS
HAMSTERS
HETEROCYCLIC COMPOUNDS
IMIDAZOLES
IN VITRO
IONIZING RADIATIONS
IRRADIATION
MAMMALS
NONMETALS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC SULFUR COMPOUNDS
OXYGEN
RADIATION EFFECTS
RADIATIONS
RADIOPROTECTIVE SUBSTANCES
RADIOSENSITIVITY
RADIOSENSITIVITY EFFECTS
RADIOSENSITIZERS
RESPONSE MODIFYING FACTORS
RODENTS
SURVIVAL TIME
THIOLS
VERTEBRATES
X RADIATION