In vitro studies on the radioresistance of oxic and hypoxic cells in the presence of both radioprotective and radiosensitizing drugs. [x rays; CHO cells; cysteine; Ro-07-0582(1-2-hydroxy-3-methoxypropyl-2-nitroimidazole)]

Journal Article · Fri Sep 01 00:00:00 EDT 1978 · Radiat. Res.; (United States)

DOI:https://doi.org/10.2307/3574843· OSTI ID:6572605

Yuhas, J M; Li, A P

In vitro studies, involving CHO monolayers, have demonstrated that the oxygenation status of the cells determines whether radioprotection or radiosensitization will be observed when both Ro-07-0582 (6 mM) and cysteine (8 mM) are present in the medium. This combination sensitizes hypoxic cells yet protects well-oxygenated ones. A comparison of individual drug effects on radiation resistance with those of the combination indicates that the latter can yield a larger therapeutic gain than either alone through reduction of drug toxicity and/or by improving relative tumor response.

• Research Organization: Univ. of New Mexico, Albuquerque
• OSTI ID: 6572605
• Journal Information: Radiat. Res.; (United States), Vol. 75:3
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
RADIOSENSITIVITY
ANOXIA
RESPONSE MODIFYING FACTORS
CYSTEINE
RADIOSENSITIVITY EFFECTS
IMIDAZOLES
OXYGEN
RADIOPROTECTIVE SUBSTANCES
COMPARATIVE EVALUATIONS
RADIOSENSITIZERS
BIOLOGICAL RADIATION EFFECTS
CELL CULTURES
HAMSTERS
IN VITRO
IRRADIATION
ORGANIC NITROGEN COMPOUNDS
SURVIVAL TIME
X RADIATION
AMINO ACIDS
ANIMALS
AZOLES
BIOLOGICAL EFFECTS
CARBOXYLIC ACIDS
CRYOGENIC FLUIDS
DRUGS
ELECTROMAGNETIC RADIATION
ELEMENTS
FLUIDS
HETEROCYCLIC COMPOUNDS
IONIZING RADIATIONS
MAMMALS
NONMETALS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
RADIATION EFFECTS
RADIATIONS
RODENTS
THIOLS
VERTEBRATES
560121* - Radiation Effects on Cells- External Source- (-1987)