Radiosensitization of mouse spermatogenic stem cells by Ro-07-0582. [Hyperbaric oxygen]
Journal Article
·
· Radiat. Res.; (United States)
The hypoxic character of the spermatogenic stem cells of the mouse testis was investigated by measuring the effect on radiosensitivity of treatment with the hypoxic cell radiosensitizer, Ro-07-0582 or hyperbaric oxygen (30 psi). The D/sub 0/ values obtained were 181 (161-207) rad for irradiation alone, 140 (133-148) rad for irradiation after treatment with Ro-07-0582, and about 100 rad for irradiation in the presence of hyperbaric oxygen. Ro-07-0582 alone was slightly cytotoxic. The results demonstrate that mouse spermatogenic stem cells are radiosensitized by Ro-07-0582 or hyperbaric oxygen and are not as well oxygenated as other normal tissues.
- Research Organization:
- Univ. of Texas, Houston
- OSTI ID:
- 7259833
- Journal Information:
- Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 69:3; ISSN RAREA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560121* -- Radiation Effects on Cells-- External Source-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
ANOXIA
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
CRYOGENIC FLUIDS
DRUGS
ELECTROMAGNETIC RADIATION
ELEMENTS
FLUIDS
GAMETOGENESIS
GAMMA RADIATION
GONADS
IONIZING RADIATIONS
MALE GENITALS
MAMMALS
MICE
NONMETALS
ORGANS
OXYGEN
RADIATION EFFECTS
RADIATIONS
RADIOSENSITIVITY EFFECTS
RODENTS
SOMATIC CELLS
SPERMATOGENESIS
STEM CELLS
TESTES
VERTEBRATES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
ANOXIA
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
CRYOGENIC FLUIDS
DRUGS
ELECTROMAGNETIC RADIATION
ELEMENTS
FLUIDS
GAMETOGENESIS
GAMMA RADIATION
GONADS
IONIZING RADIATIONS
MALE GENITALS
MAMMALS
MICE
NONMETALS
ORGANS
OXYGEN
RADIATION EFFECTS
RADIATIONS
RADIOSENSITIVITY EFFECTS
RODENTS
SOMATIC CELLS
SPERMATOGENESIS
STEM CELLS
TESTES
VERTEBRATES