Radiosensitizing and toxic effects of the 2-nitroimidazole Ro-07-0582 in hypoxic mammalian cells. [Gamma radiation]
The properties of the electron-affinic 2-nitroimidazole Ro-07-0582 have been examined in vitro in two Chinese hamster cell lines, CHO and CH2B/sub 2/. The drug was found to sensitize hypoxic cells to radiation damage selectively with a high efficiency. At concentrations greater than 10 mM the drug has a dose-modifying factor of approximately 3.0 in hypoxic cultures. It does not alter the response of aerobic cells. Pre- or postirradiation treatment of cells with Ro-07-0582 has little, if any, effect. At high cell concentrations, where many sensitizers are ineffective, this compound retains most of its radiosensitizing capability. Ro-07-0582 is also shown to have a chemotherapeutic potential in that it demonstrates a very selective toxicity for hypoxic cells after a few hours of exposure. It is much less toxic to aerobic cells. This property, while it may serve as a useful complement to the radiosensitizing effect of the drug, suggests that care must be exercized in the clinical application of Ro-07-0582 to avoid possible injury to normal hypoxic tissues in the body.
- Research Organization:
- British Columbia Cancer Foundation, Vancouver
- OSTI ID:
- 7333896
- Journal Information:
- Radiat. Res.; (United States), Vol. 67:3
- Country of Publication:
- United States
- Language:
- English
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Ro-07-0582 as a radiosensitizer and cytotoxic agent. [Nitroimidazoles, nitrofurans]
Related Subjects
ANIMAL CELLS
BIOLOGICAL RADIATION EFFECTS
ANOXIA
RADIOSENSITIVITY EFFECTS
IMIDAZOLES
GAMMA RADIATION
HAMSTERS
TOXICITY
ANIMALS
AZOLES
BIOLOGICAL EFFECTS
ELECTROMAGNETIC RADIATION
HETEROCYCLIC COMPOUNDS
IONIZING RADIATIONS
MAMMALS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
RADIATION EFFECTS
RADIATIONS
RODENTS
VERTEBRATES
560121* - Radiation Effects on Cells- External Source- (-1987)