Radiosensitizing and toxic effects of the 2-nitroimidazole Ro-07-0582 in hypoxic mammalian cells. [Gamma radiation]
Journal Article
·
· Radiat. Res.; (United States)
The properties of the electron-affinic 2-nitroimidazole Ro-07-0582 have been examined in vitro in two Chinese hamster cell lines, CHO and CH2B/sub 2/. The drug was found to sensitize hypoxic cells to radiation damage selectively with a high efficiency. At concentrations greater than 10 mM the drug has a dose-modifying factor of approximately 3.0 in hypoxic cultures. It does not alter the response of aerobic cells. Pre- or postirradiation treatment of cells with Ro-07-0582 has little, if any, effect. At high cell concentrations, where many sensitizers are ineffective, this compound retains most of its radiosensitizing capability. Ro-07-0582 is also shown to have a chemotherapeutic potential in that it demonstrates a very selective toxicity for hypoxic cells after a few hours of exposure. It is much less toxic to aerobic cells. This property, while it may serve as a useful complement to the radiosensitizing effect of the drug, suggests that care must be exercized in the clinical application of Ro-07-0582 to avoid possible injury to normal hypoxic tissues in the body.
- Research Organization:
- British Columbia Cancer Foundation, Vancouver
- OSTI ID:
- 7333896
- Journal Information:
- Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 67:3; ISSN RAREA
- Country of Publication:
- United States
- Language:
- English
Similar Records
Ro-07-0582 as a radiosensitizer and cytotoxic agent. [Nitroimidazoles, nitrofurans]
Radiosensitizing and toxic effects of the 2-nitroimidazole Ro-07-0582 in different phases of the cell cycle of extremely hypoxic human cells in vitro
Selective radiosensitization of the hypoxic cells of mouse tumors with the nitroimidazoles metronidazole and Ro 7-0582
Journal Article
·
Fri Dec 31 23:00:00 EST 1976
· Int. J. Radiat. Oncol., Biol. Phys.; (United States)
·
OSTI ID:5334042
Radiosensitizing and toxic effects of the 2-nitroimidazole Ro-07-0582 in different phases of the cell cycle of extremely hypoxic human cells in vitro
Journal Article
·
Sat Dec 31 23:00:00 EST 1977
· Radiat. Res.; (United States)
·
OSTI ID:7075815
Selective radiosensitization of the hypoxic cells of mouse tumors with the nitroimidazoles metronidazole and Ro 7-0582
Journal Article
·
Sun Nov 30 23:00:00 EST 1975
· Radiat. Res., v. 64, no. 3, pp. 633-647
·
OSTI ID:4116038
Related Subjects
560121* -- Radiation Effects on Cells-- External Source-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
ANOXIA
AZOLES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
ELECTROMAGNETIC RADIATION
GAMMA RADIATION
HAMSTERS
HETEROCYCLIC COMPOUNDS
IMIDAZOLES
IONIZING RADIATIONS
MAMMALS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
RADIATION EFFECTS
RADIATIONS
RADIOSENSITIVITY EFFECTS
RODENTS
TOXICITY
VERTEBRATES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
ANOXIA
AZOLES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
ELECTROMAGNETIC RADIATION
GAMMA RADIATION
HAMSTERS
HETEROCYCLIC COMPOUNDS
IMIDAZOLES
IONIZING RADIATIONS
MAMMALS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
RADIATION EFFECTS
RADIATIONS
RADIOSENSITIVITY EFFECTS
RODENTS
TOXICITY
VERTEBRATES