Ro-07-0582 as a radiosensitizer and cytotoxic agent. [Nitroimidazoles, nitrofurans]
- Coll. of Physicians and Surgeons of Columbia Univ., New York
The electron affinic drugs, including the nitroimidazoles and the nitrofurans, were initially identified on the basis of their ability to mimic oxygen and differentially sensitize hypoxic cells. More recently, these drugs have been found to exhibit selective toxicity toward hypoxic cells. The radiosensitizing effect of the 2-nitroimidazole Ro-07-0582 is greatly enhanced if cells are pre-incubated in the presence of the drug for a period of hours prior to irradiation. In addition, the cytotoxicity of the drug is greatly increased at elevated temperatures. Both of these effects may be related to the metabolism of the drug, and it is clear that there is considerable room for maneuver in the time sequence of administering the drug and delivering the radiation dose as these potent and useful sensitizers begin to be used in the human.
- OSTI ID:
- 5334042
- Journal Information:
- Int. J. Radiat. Oncol., Biol. Phys.; (United States), Vol. 2:5/6
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
ANIMAL CELLS
RADIOSENSITIVITY
FURANS
RADIOSENSITIZERS
TOXICITY
IMIDAZOLES
NITRO COMPOUNDS
DRUGS
HAMSTERS
OXYGEN
RADIATION DOSES
ANIMALS
AZOLES
CRYOGENIC FLUIDS
DOSES
ELEMENTS
FLUIDS
HETEROCYCLIC COMPOUNDS
MAMMALS
NONMETALS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
RESPONSE MODIFYING FACTORS
RODENTS
VERTEBRATES
560121* - Radiation Effects on Cells- External Source- (-1987)