Combined radiotherapy and Corynebacterium parvum treatment of rat tumors with different immunogenicity. [X rays]

Journal Article · Sun Jan 01 00:00:00 EST 1978 · Int. J. Radiat. Oncol., Biol. Phys.; (United States)

DOI:https://doi.org/10.1016/0360-3016(78)90188-8· OSTI ID:6540434

Moroson, H; Stowe, S; Rotman, M; Schechter, M

Evidence is presented that combined radiotherapy and Corynebacterium parvum treatment gives better results than radiotherapy alone in rats bearing a chemically-induced highly-immunogenic transplanted fibrosarcoma termed BP 179; however, similar behavior is not observed with either of two weakly-immunogenic mammary carcinomas, 13762 or ME/H. Relative immunogenicity is determined by the ability of immunized rats to reject tumor cell challenge. Both 13762 and ME/H carcinomata grow progressively and metastasize early to the retroperitoneal cavity and lungs if they are left untreated. Local radiotherapy of the primary tumor has no influence on growth of metastases whether it is combined with C. parvum or not. Results of cell-mediated cytotoxicity studies with lymphocytes from BP 179 and ME/H tumor bearing rats treated with radiation or radiation plus C. parvum support the in vivo findings of combined radiotherapy. These data suggest that unlike strongly immunogenic tumors, weakly immunogenic tumors will not respond better to C. parvum combined with radiation therapy.

• Research Organization: New York Medical Coll., NY
• OSTI ID: 6540434
• Journal Information: Int. J. Radiat. Oncol., Biol. Phys.; (United States), Vol. 4:7-8
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
62 RADIOLOGY AND NUCLEAR MEDICINE
59 BASIC BIOLOGICAL SCIENCES
FIBROSARCOMAS
IMMUNOTHERAPY
RADIOTHERAPY
EFFICIENCY
SYNERGISM
CORYNEBACTERIUM PARVUM
LEGS
LOCAL IRRADIATION
RATS
TRANSPLANTS
TUMOR CELLS
X RADIATION
ANIMAL CELLS
ANIMALS
BACTERIA
BODY
BODY AREAS
DISEASES
ELECTROMAGNETIC RADIATION
IONIZING RADIATIONS
IRRADIATION
LIMBS
MAMMALS
MEDICINE
MICROORGANISMS
NEOPLASMS
NUCLEAR MEDICINE
RADIATIONS
RADIOLOGY
RODENTS
SARCOMAS
THERAPY
VERTEBRATES
560152* - Radiation Effects on Animals- Animals
550600 - Medicine
551000 - Physiological Systems