Responsiveness of senescent mice to the antitumor properties of Corynebacterium parvum

Journal Article · Thu Jan 01 04:00:00 EST 1976 · Cancer Res.; (United States)

OSTI ID:7350728

Yuhas, J M; Ullrich, R L

The antitumor properties of Corynebacterium parvum have been studied in young (3- to 8-month-old) and aged (18 or more months old) BALB/c mice given s.c., i.m., i.p., or i.v. transplants of the highly malignant, weakly immunogenic line 1 lung carcinoma, and aged (25- to 33-month-old) BALB/c mice bearing primary mammary tumors. These aged BALB/c mice were shown to be less immunoresponsive than their younger counterparts, and this, in combination with nonimmunological factors, made them more sensitive to the lethal effects of the line 1 carcinoma. Correspondingly, C. parvum proved to have less antitumor activity in aged mice than it did in young mice. In spite of this relatively weaker, antitumor activity for C. parvum in aged mice, repeated injections of this agent were able to induce temporary regressions of the primary mammary tumors studied and thereby prolong survival time.

• Research Organization: Oak Ridge National Lab., TN
• OSTI ID: 7350728
• Journal Information: Cancer Res.; (United States), Journal Name: Cancer Res.; (United States) Vol. 36; ISSN CNREA
• Country of Publication: United States
• Language: English

Related Subjects

550900* -- Pathology
59 BASIC BIOLOGICAL SCIENCES
AGE DEPENDENCE
ANIMALS
BACTERIA
BIOLOGICAL EFFECTS
BODY
CARCINOMAS
DISEASES
GLANDS
IMMUNE REACTIONS
LUNGS
MAMMALS
MAMMARY GLANDS
MICE
MICROORGANISMS
NEOPLASMS
ORGANS
RESPIRATORY SYSTEM
RODENTS
SURVIVAL TIME
VERTEBRATES