Combined radiotherapy and Corynebacterium parvum treatment of rat tumors with different immunogenicity. [X rays]
Journal Article
·
· Int. J. Radiat. Oncol., Biol. Phys.; (United States)
Evidence is presented that combined radiotherapy and Corynebacterium parvum treatment gives better results than radiotherapy alone in rats bearing a chemically-induced highly-immunogenic transplanted fibrosarcoma termed BP 179; however, similar behavior is not observed with either of two weakly-immunogenic mammary carcinomas, 13762 or ME/H. Relative immunogenicity is determined by the ability of immunized rats to reject tumor cell challenge. Both 13762 and ME/H carcinomata grow progressively and metastasize early to the retroperitoneal cavity and lungs if they are left untreated. Local radiotherapy of the primary tumor has no influence on growth of metastases whether it is combined with C. parvum or not. Results of cell-mediated cytotoxicity studies with lymphocytes from BP 179 and ME/H tumor bearing rats treated with radiation or radiation plus C. parvum support the in vivo findings of combined radiotherapy. These data suggest that unlike strongly immunogenic tumors, weakly immunogenic tumors will not respond better to C. parvum combined with radiation therapy.
- Research Organization:
- New York Medical Coll., NY
- OSTI ID:
- 6540434
- Journal Information:
- Int. J. Radiat. Oncol., Biol. Phys.; (United States), Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Vol. 4:7-8; ISSN IOBPD
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550600 -- Medicine
551000 -- Physiological Systems
560152* -- Radiation Effects on Animals-- Animals
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BACTERIA
BODY
BODY AREAS
CORYNEBACTERIUM PARVUM
DISEASES
EFFICIENCY
ELECTROMAGNETIC RADIATION
FIBROSARCOMAS
IMMUNOTHERAPY
IONIZING RADIATIONS
IRRADIATION
LEGS
LIMBS
LOCAL IRRADIATION
MAMMALS
MEDICINE
MICROORGANISMS
NEOPLASMS
NUCLEAR MEDICINE
RADIATIONS
RADIOLOGY
RADIOTHERAPY
RATS
RODENTS
SARCOMAS
SYNERGISM
THERAPY
TRANSPLANTS
TUMOR CELLS
VERTEBRATES
X RADIATION
551000 -- Physiological Systems
560152* -- Radiation Effects on Animals-- Animals
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BACTERIA
BODY
BODY AREAS
CORYNEBACTERIUM PARVUM
DISEASES
EFFICIENCY
ELECTROMAGNETIC RADIATION
FIBROSARCOMAS
IMMUNOTHERAPY
IONIZING RADIATIONS
IRRADIATION
LEGS
LIMBS
LOCAL IRRADIATION
MAMMALS
MEDICINE
MICROORGANISMS
NEOPLASMS
NUCLEAR MEDICINE
RADIATIONS
RADIOLOGY
RADIOTHERAPY
RATS
RODENTS
SARCOMAS
SYNERGISM
THERAPY
TRANSPLANTS
TUMOR CELLS
VERTEBRATES
X RADIATION