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Combined use of local irradiation and corynebacterium parvum in the treatment of the murine line 1 lung carcinoma

Journal Article · · Radiat. Res.; (United States)
DOI:https://doi.org/10.2307/3574819· OSTI ID:7276879
;
The effectiveness of Corynebacterium parvum in combination with local irradiation has been examined in the treatment of the murine line 1 lung carcinoma, a highly radioresistant, weakly immunogenic tumor that kills the host by means of metastatic spread. Sixteen-week-old, specific-pathogen-free female BABL/c mice were given 10/sup 6/ tumor cells im into the right thigh. Tumors were irradiated on Day 7 after transplant. Those receiving C. parvum treatment were given 0.1 mg either by the intralesional (il), ip, or iv route on Day 4 after transplant or by the il or ip route on Day 8. An additional group received C. parvum ip once a week for 4 weeks beginning on Day 8. The influence of the various treatments on local control and metastasis was assessed. To evaluate further the time course and incidence of metastases, cleared lungs were examined at 21, 28, and 35 days in groups given irradiation combined with C. parvum on day 8. C. parvum was more effective in facilitating local control and inhibiting metastatic spread when given after radiation exposure rather than before.
Research Organization:
Oak Ridge National Lab., TN
OSTI ID:
7276879
Journal Information:
Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 73:2; ISSN RAREA
Country of Publication:
United States
Language:
English

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Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BACTERIA
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BODY AREAS
CARCINOMAS
CORYNEBACTERIUM PARVUM
DISEASES
ELECTROMAGNETIC RADIATION
IMMUNOTHERAPY
INHIBITION
IONIZING RADIATIONS
IRRADIATION
LEGS
LIMBS
LOCAL IRRADIATION
MAMMALS
MEDICINE
METASTASES
MICE
MICROORGANISMS
NEOPLASMS
NUCLEAR MEDICINE
RADIATION EFFECTS
RADIATIONS
RADIOLOGY
RADIOTHERAPY
RODENTS
THERAPY
TRANSPLANTS
VERTEBRATES
X RADIATION