Naturally arising tumors of the inbred WAB/Not rat strain. II. Immunogenicity of transplanted tumors

Journal Article · Tue Sep 01 04:00:00 EDT 1981 · J. Natl. Cancer Inst.; (United States)

OSTI ID:5462881

Middle, J G; Embleton, M J

The immunogenicity of 28 transplanted naturally arising tumors of the inbred WAB/Not rat was investigated at early passages in strictly syngeneic, contemporary animals. Included were nephroblastomas, histologically benign and malignant mammary tumors, soft tissue and skin tumors, 1 lymphoid tumor, and 2 gastrointestinal lesions. In no case was evidence of immunogenicity observed when animals were treated with multiple grafts of irradiated (15,000 rad) tissue or by excision of a growing tumor. A few of these tumors were further investigated by other methods of immunization, including injection at various sites of irradiated cells followed by challenge at different sites and multiple injections of mitomycin C- or Formalin-treated cells. Again no evidence of immunogenicity was seen. Attempts to immunize with viable cells mixed with BCG or Corynebacterium parvum failed due to lack of tumor suppression by these agents. Limited concomitant immunity experiments yielded similarly negative results, except in one case of a fibrosarcoma for which a slight reduction in second tumor growth was observed when primary implants were very large. Some alterations in biologic properties during transplant passage and the incidence of postexcision recurrence and metastatic spread of some of the tumors are described.

• OSTI ID: 5462881
• Journal Information: J. Natl. Cancer Inst.; (United States), Journal Name: J. Natl. Cancer Inst.; (United States) Vol. 67:3; ISSN JNCIA
• Country of Publication: United States
• Language: English

Related Subjects

552000 -- Public Health
560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
99 GENERAL AND MISCELLANEOUS
ANIMALS
DISEASES
EXTERNAL IRRADIATION
GRAFT-HOST REACTION
IMMUNITY
IMMUNOLOGY
IRRADIATION
MAMMALS
METASTASES
NEOPLASMS
RADIOIMMUNOLOGY
RATS
RODENTS
TRANSPLANTS
VERTEBRATES