Modification of the immunogenic properties of chemically induced tumors arising in hosts treated concomitantly with ultraviolet light
Journal Article
·
· J. Immunol.; (United States)
OSTI ID:6865916
Experiments were conducted to determine whether the immunogenic properties of tumors induced in mice possessing a specific state of immunologic unresponsiveness were different from those that were generated in normal mice. Several parameters related to tumor induction by chemical carcinogens in mice exposed to ultraviolet light (UV) were studied. In addition to observed reduced latency periods for tumors induced by benz(a)pyrene and methylcholantrene (MCA) in mice pretreated wth UV, the secondary growth charateristics of the MCA tumors generated in these hosts were dissimilar from those that arose in normal animals. Contrary to the notion that most chemically induced tumors are capable of progressive growth when transplanted into normal syngeneic hosts, a high proportion of the MCA tumors induced in UV-treated mice were highly antigenic. Our data sugest that the immunogenic properties of a tumor may be influenced by the immunologic status of the host at the time of tumor development. Thus, it might be postulated that a pre-existing immunoregulatory response toward a particular antigenic determinant may occlude the immune system's ability to recognize and eliminate certain nascent tumor cells that also express that antigen.
- Research Organization:
- Utah Univ., Salt Lake City
- OSTI ID:
- 6865916
- Journal Information:
- J. Immunol.; (United States), Journal Name: J. Immunol.; (United States) Vol. 125:1; ISSN JOIMA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550900 -- Pathology
551000 -- Physiological Systems
560152* -- Radiation Effects on Animals-- Animals
560305 -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
AROMATICS
BENZOPYRENE
BIOLOGICAL EFFECTS
CARCINOGENESIS
CONDENSED AROMATICS
DISEASES
ELECTROMAGNETIC RADIATION
HYDROCARBONS
IMMUNE REACTIONS
IMMUNOSUPPRESSION
MAMMALS
MICE
NEOPLASMS
ORGANIC COMPOUNDS
PATHOGENESIS
PATHOLOGICAL CHANGES
RADIATION EFFECTS
RADIATIONS
RODENTS
SYNERGISM
TUMOR CELLS
ULTRAVIOLET RADIATION
VERTEBRATES
551000 -- Physiological Systems
560152* -- Radiation Effects on Animals-- Animals
560305 -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
AROMATICS
BENZOPYRENE
BIOLOGICAL EFFECTS
CARCINOGENESIS
CONDENSED AROMATICS
DISEASES
ELECTROMAGNETIC RADIATION
HYDROCARBONS
IMMUNE REACTIONS
IMMUNOSUPPRESSION
MAMMALS
MICE
NEOPLASMS
ORGANIC COMPOUNDS
PATHOGENESIS
PATHOLOGICAL CHANGES
RADIATION EFFECTS
RADIATIONS
RODENTS
SYNERGISM
TUMOR CELLS
ULTRAVIOLET RADIATION
VERTEBRATES