Evidence for two functionally distinct cross-reactive tumor antigens associated with ultraviolet light and chemically induced tumors. [Mice; /sup 137/Cs]

Journal Article · Thu Apr 01 04:00:00 EST 1982 · Transplantation; (United States)

OSTI ID:6722432

Roberts, L K; Lynch, D H; Daynes, B A

Experiments were conducted to determine the distribution and function of common tumor antigens shared by ultraviolet light (UV)-, benz(a)pyrene (BP)-, and methylcholanthrene (MCA)-induced tumors. When lymph node cells were removed from UV, BP, or MCA tumor-immune mice and held in tissue culture for 4 days, a population of cytotoxic T lymphocytes (CTLs) emerged that were capable of lysing a battery of different tumor targets. The data defined at least two different classes of common tumor antigens expressed by UV and chemically induced tumors. These antigenic determinants are functionally defined as the TATAs and the common TAAs. The shared TATA function in vivo as rejection antigens and are restricted to tumors induced by the same carcinogenic agent. In contrast, the common TAAs shared by UV and chemically induced tumors are not only recognized by CTLs but more importantly function as immunoregulatory determinants. The importance of these common tumor antigens in host-tumor interactions is discussed. (JMT)

• Research Organization: Univ. of Utah Medical Center, Salt Lake City
• OSTI ID: 6722432
• Journal Information: Transplantation; (United States), Journal Name: Transplantation; (United States) Vol. 33:4; ISSN TRPLA
• Country of Publication: United States
• Language: English

Related Subjects

3-METHYLCHOLANTHRENE
551000 -- Physiological Systems
560152* -- Radiation Effects on Animals-- Animals
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKALI METAL ISOTOPES
ANIMAL CELLS
ANIMALS
ANTIGENS
AROMATICS
BENZOPYRENE
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL FUNCTIONS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CESIUM 137
CESIUM ISOTOPES
CONDENSED AROMATICS
CONNECTIVE TISSUE CELLS
DISEASES
DISTRIBUTION
ELECTROMAGNETIC RADIATION
EXTERNAL IRRADIATION
FAR ULTRAVIOLET RADIATION
FUNCTIONS
GAMMA RADIATION
HYDROCARBONS
IMMUNOLOGY
IMMUNOSUPPRESSION
IONIZING RADIATIONS
IRRADIATION
ISOTOPES
LEUKOCYTES
LYMPHOCYTES
MAMMALS
MATERIALS
MICE
NEOPLASMS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
POLYCYCLIC AROMATIC HYDROCARBONS
RADIATIONS
RADIOINDUCTION
RADIOISOTOPES
RODENTS
SOMATIC CELLS
TISSUE DISTRIBUTION
ULTRAVIOLET RADIATION
VERTEBRATES
WHOLE-BODY IRRADIATION
YEARS LIVING RADIOISOTOPES