Organ distribution of technetium-99m-labeled Corynebacterium parvum in normal and tumor-bearing mice

Journal Article · Sun Jan 01 04:00:00 EST 1978 · Cancer Res.; (United States)

OSTI ID:7026974

Barth, R F; Singla, O

The distribution patterns were studied for /sup 99m/Tc-labeled Corynebacterium parvum in normal and tumor-bearing mice. C57BL/6 mice were given i.v., i.p., or s.c. injections of 250 ..mu..g of /sup 99m/Tc-labeled C. parvum and killed at 10 min, 1, 4, and 24 hr. After iv. administration, labeled organisms were distributed primarily to the liver, the lungs, and the blood (46% of injected dose), followed by the gastrointestinal tract, the spleen, and the kidneys (11%). Total recoverable radioactivity, which was defined as the percentage of injected dose that was recovered, ranged from 59% at 10 min to 15% at 24 hr. In contrast to this, /sup 99m/TcS colloid, an inert particulate material, was localized almost entirely in the liver, and the amount recoverable remained constant over 24 hr. One hr after i.p. administration of /sup 99m/Tc-labeled C. parvum, the gastrointestinal tract accounted for 27% of the injected radioactivity, followed by liver, blood, and spleen (12%). This was rapidly excreted between 4 and 24 hr, at which time only 12% of the injected dose was recovered. The skin accounted for 54.6% of the injected radioactivity 1 hr after s.c. injection, 6% 4 hr after s.c. injection, and 0.8% at 24 hr after s.c. injection.

• Research Organization: Univ. of Kansas, Kansas City
• OSTI ID: 7026974
• Journal Information: Cancer Res.; (United States), Journal Name: Cancer Res.; (United States) Vol. 38:1; ISSN CNREA
• Country of Publication: United States
• Language: English

Related Subjects

550600* -- Medicine
550601 -- Medicine-- Unsealed Radionuclides in Diagnostics
550700 -- Microbiology
550900 -- Pathology
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BLOOD
BODY
BODY FLUIDS
DIGESTIVE SYSTEM
DISEASES
DISTRIBUTION
GASTROINTESTINAL TRACT
GLANDS
HOURS LIVING RADIOISOTOPES
IMMUNE REACTIONS
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LABELLING
LIVER
LUNGS
LYMPH NODES
LYMPHATIC SYSTEM
MAMMALS
MEDICINE
MICE
MICROORGANISMS
NEOPLASMS
NUCLEI
ODD-EVEN NUCLEI
ORGANS
RADIOISOTOPES
RESPIRATORY SYSTEM
RETICULOENDOTHELIAL SYSTEM
RODENTS
SKIN
SPLEEN
TECHNETIUM 99
TECHNETIUM ISOTOPES
THERAPY
TIME DEPENDENCE
TISSUE DISTRIBUTION
TISSUES
VERTEBRATES
YEARS LIVING RADIOISOTOPES