Production rate of an isotachic train in displacement chromatography
Journal Article
·
· AIChE Journal (American Institute of Chemical Engineers); (United States)
- Univ. of Tennessee, Knoxville, TN (United States). Dept. of Chemistry Oak Ridge National Lab., TN (United States). Chemical and Analytical Sciences Div.
The shock layer theory permits the derivation of an equation relating the thickness of the shock layer or mixed zone between successive bands in a fully developed isotachic train and the experimental parameters (mobile-phase flow velocity, concentration and retention factor of the displacer. column length, and average particle size of the packing material). It also permits the calculation of the amount of each product contained in this mixed zone. The main assumptions made are the use of the competitive Langmuir isotherm, the identity of axial dispersion coefficients, and the mass-transfer rate constants for different components. These equations make it possible to calculate the production rate and recovery yield achieved with an isotachic train, and to optimize the experimental conditions for maximum production rate. The shock layer thickness increases rapidly and the production rate decreases sharply when [alpha] [minus] 1 tends toward 0. In agreement with previous experimental results, there are well defined optimum flow velocity and displacer concentrations which vary depending on feed components. This theory permits an easy access to the optimization of these parameters.
- OSTI ID:
- 6538606
- Journal Information:
- AIChE Journal (American Institute of Chemical Engineers); (United States), Journal Name: AIChE Journal (American Institute of Chemical Engineers); (United States) Vol. 41:1; ISSN 0001-1541; ISSN AICEAC
- Country of Publication:
- United States
- Language:
- English
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