Influence of spironolactone on the excretion of /sup 203/Hg/sup 2 +/ in rats

Journal Article · Wed Jan 01 04:00:00 EST 1975 · Environ. Res.; (United States)

OSTI ID:6537692

Cikrt, M; Tichy, M

The effect of Spironolactone (SPL) on /sup 203/Hg/sup 2 +/ excretion was studied in rats with particular attention to mercury excretion via the bile. No correlation was found between the number of SPL (premedication by 1 to 5 doses of 5 mg SPL/100 g body weight) and the cumulative bile excretion of /sup 203/Hg/sup 2 +/ during 6 hours after an i.v. administration of 120 ..mu..g Hg/sup 2 +/ per rat. After SPL premedication there was a statistically significant increase of mercury excretion in stool 24 hrs after an i.v. administration of /sup 203/Hg/sup 2 +/. A simultaneous peroral administration of the sorbent containing SH-groups had no effect on mercury excretion in stool. Repeated administrations of /sup 203/Hg/sup 2 +/ (5 hours after the first dose) produced a statistically significant increase of mercury excretion via bile in rats which had previously received SPL. Conversely, repeated administrations of SPL (4 hours after i.v. application of mercury) failed to influence mercury bile excretion. The results indicate that the effect of SPL on mercury bile excretion is limited by the level of ''accessible mercury'' in the organism and could be determined by direct interaction of the mercury and SPL molecules.

• OSTI ID: 6537692
• Journal Information: Environ. Res.; (United States), Journal Name: Environ. Res.; (United States) Vol. 10; ISSN ENVRA
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BILE
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BODY FLUIDS
CHRONIC INTAKE
CLEARANCE
DAYS LIVING RADIOISOTOPES
EVEN-ODD NUCLEI
EXCRETION
FECES
HEAVY NUCLEI
INGESTION
INJECTION
INTAKE
INTRAVENOUS INJECTION
ISOTOPES
MAMMALS
MERCURY 203
MERCURY ISOTOPES
NUCLEI
RADICALS
RADIOISOTOPES
RATS
RODENTS
STIMULATION
SULFHYDRYL RADICALS
VERTEBRATES
WASTES