Metabolism of Mercurascan-$sup 203$Hg by rats and dogs

Journal Article · Mon Jan 01 04:00:00 EST 1973 · J. Nucl. Biol. Med., v. 17, no. 2, pp. 43-50

OSTI ID:4406736

Dreyfuss, J; Ross, Jr, J J; Shaw, J M

rats and dogs. Blood levels of total radioactivity were similar in both species, and no significant differences were found in the kinetics of elimination. Radioactivity was 97% bound to plasma proteins of a dog. Tissues of rats or dogs did not appear to concentrate radioactivity, with the exception of the kidneys and liver. Radioactivity in the kidneys of rats or dogs was excreted very slowly, but most of the radioactivity in the livers of rats was eliminated in 4 days. The excretion of Mercurascan-/sup 203/Hg by both species was predominantly in the feces; the bile is the source of the radioactivity excreted in the feces. Most of the radioactivity found in the feces of rats and dogs was excreted during the first 24 hrs after animals had been dosed, but radioactivity continued to be excreted by dogs in the urine and feces in small amounts for at least 3 weeks. Dog bile contains a glucuronide conjugate of one or more of the mercurial derivatives of fluorescein. Two metabolites were excreted in rat urine and at least one in rat feces that are chromatographically different from any of the principal components of mercurascan-/sup 203/Hg. These results indicate that s and dogs. (auth)

• Research Organization: Squibb Inst. for Medical Research, New Brunswick, NJ
• NSA Number: NSA-29-002954
• OSTI ID: 4406736
• Journal Information: J. Nucl. Biol. Med., v. 17, no. 2, pp. 43-50, Journal Name: J. Nucl. Biol. Med., v. 17, no. 2, pp. 43-50; ISSN JNBMA
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

*DOGS-- RADIONUCLIDE KINETICS
*MERCURY 203-- METABOLISM
*RATS-- RADIONUCLIDE KINETICS
EXCRETION
FECES
INTRAVENOUS INJECTION
KIDNEYS
LABELLED COMPOUNDS
LIVER
N48720* --Life Sciences--Nuclide Kinetics & Toxicology-- Animals
TISSUE DISTRIBUTION
URINE