Metabolism of ethylmercuric chloride-/sup 203/Hg in rats

Journal Article · Thu Jan 01 04:00:00 EST 1970 · Toxicol. Appl. Pharmacol.; (United States)

DOI:https://doi.org/10.1016/0041-008X(70)90142-0· OSTI ID:6097477

Takeda, Y; Ukita, T

Methods for the analysis of the mercury compounds in biological samples were established and applied to the investigation of the metabolic fate of ethylmercuric chloride-/sup 203/Hg in rats. Analyses of mercury compounds contained in the liver, kidney, urine, and feces of rats treated with ethylmercuric chloride-/sup 203/Hg (20 mg Hg/kg, sc) indicated that the content of organic mercury in the kidney was higher than in the liver, that the former increased with time, and that the organic mercury content in feces was higher than in the urine. The organic mercury compound in these organs and excreta was identified as the ethylmercury derivative, and mercury metabolites other than inorganic mercury were not detected. The mercury compound seemed to be bound to protein in the organs. 12 references, 3 figures, 6 tables.

• Research Organization: Univ. of Tokyo, Bunkyo-ku, Japan
• OSTI ID: 6097477
• Journal Information: Toxicol. Appl. Pharmacol.; (United States), Journal Name: Toxicol. Appl. Pharmacol.; (United States) Vol. 17; ISSN TXAPA
• Country of Publication: United States
• Language: English

Related Subjects

550500* -- Metabolism
59 BASIC BIOLOGICAL SCIENCES
ANIMALS
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BODY
BODY FLUIDS
DATA
DIGESTIVE SYSTEM
DISTRIBUTION
EXPERIMENTAL DATA
FECES
GLANDS
INFORMATION
KIDNEYS
LIVER
MAMMALS
MATERIALS
MERCURY COMPOUNDS
METABOLISM
NUMERICAL DATA
ORGANIC COMPOUNDS
ORGANIC MERCURY COMPOUNDS
ORGANS
RATS
RODENTS
TISSUE DISTRIBUTION
URINE
VERTEBRATES
WASTES