Influence of spironolactone on the excretion of /sup 203/Hg/sup 2 +/ in rats
Journal Article
·
· Environ. Res.; (United States)
OSTI ID:7224163
The effect of spironolactone (SPL) on /sup 203/Hg/sup 2 +/ excretion was studied in rats with a special emphasis in biliary excretion. No correlation was found between the number of doses of SPL pretreatment (1-5 doses of 5 mg/100 g body weight) and the biliary excretion of /sup 203/Hg/sup 2 +/ within 6 hours after intravenous administration of 120 ..mu..g Hg/sup 2 +/ per rat. After the SPL pretreatment there was a significantly increased mercury stool excretion 24 hours after intravenous administration. Concurrent oral administration of SH-groups containing sorbent had no effect on mercury stool excretion. Repeated administration of /sup 203/Hg/sup 2 +/ (5 hours after the first dose) induced significantly increased biliary excretion of mercury in rats pretreated with SPL. On the other hand, repeated administration of SPL (4 hours after intravenous administration of mercury) did not influence the biliary excretion of mercury. The results indicate that the effect of SPL on biliary excretion of mercury could be limited by the level of ''mercury available'' in the organism and might be determined by a direct interaction of mercury molecule with the molecule of SPL (or its metabolite).
- Research Organization:
- Inst. of Hygiene and Epidemiology, Prague
- OSTI ID:
- 7224163
- Journal Information:
- Environ. Res.; (United States), Journal Name: Environ. Res.; (United States) Vol. 10:3; ISSN ENVRA
- Country of Publication:
- United States
- Language:
- English
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Influence of spironolactone on the excretion of /sup 203/Hg/sup 2 +/ in rats
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· Environ. Res.; (United States)
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Sun Dec 31 23:00:00 EST 1972
· Arch. Toxikol., v. 31, no. 1, pp. 51-59
·
OSTI ID:4421012
Related Subjects
560172* -- Radiation Effects-- Nuclide Kinetics & Toxicology-- Animals-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BILIARY TRACT
CLEARANCE
DAYS LIVING RADIOISOTOPES
DIGESTIVE SYSTEM
ESTERS
EVEN-ODD NUCLEI
EXCRETION
HEAVY NUCLEI
HETEROCYCLIC COMPOUNDS
INJECTION
INTAKE
INTRAVENOUS INJECTION
ISOTOPES
LACTONES
MAMMALS
MERCURY 203
MERCURY ISOTOPES
NUCLEI
ORGANIC COMPOUNDS
RADIOISOTOPES
RADIONUCLIDE KINETICS
RATS
RODENTS
STEROIDS
VERTEBRATES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BILIARY TRACT
CLEARANCE
DAYS LIVING RADIOISOTOPES
DIGESTIVE SYSTEM
ESTERS
EVEN-ODD NUCLEI
EXCRETION
HEAVY NUCLEI
HETEROCYCLIC COMPOUNDS
INJECTION
INTAKE
INTRAVENOUS INJECTION
ISOTOPES
LACTONES
MAMMALS
MERCURY 203
MERCURY ISOTOPES
NUCLEI
ORGANIC COMPOUNDS
RADIOISOTOPES
RADIONUCLIDE KINETICS
RATS
RODENTS
STEROIDS
VERTEBRATES