Biliary excretion of mercury compounds

Journal Article · Wed Jan 01 04:00:00 EST 1975 · Toxicol. Appl. Pharmacol.; (United States)

DOI:https://doi.org/10.1016/0041-008X(75)90102-7· OSTI ID:6265739

Klaassen, C D

The disappearance of /sup 203/Hg from the plasma of rats and its excretion into bile was quantitated for 2 hr after the iv administration of 0.03, 0.1, 0.3, 1.0, and 3.0 mg Hg/kg as /sup 203/ mercuric chloride. The concentration of /sup 203/Hg in the bile was usually about 0.66 than in the plasma. The concentration of /sup 203/Hg in the liver was 1.8-3.4 times higher than that in the plasma, and the bile concentration was about three times lower than that in the plasma. Methyl mercuric chloride was given to rats at dosages of 0.1, 0.3, 1.0, and 3.0 mg Hg/kg, iv. The concentration of /sup 203/Hg in bile average about nine times higher than that in the plasma, the liver concentration was about 25-fold higher than that in the plasma and the bile concentration about 0.33 that in the liver. Thus the radioactivity associated with either mercuric chloride or methyl mercury were not highly concentrated in bile as are some other heavy metals. Over a 2-hr period, regardless of the dose or the form of Hg administered, less than 0.5% of the dose was excreted into the bile. The effect of 4 days pretreatment with phenobarbital, spironolactone, pregnenolone-16..cap alpha..-carbonitrile (PCN), and 3-methylcholanthrene on the biliary excretion of mercuric chloride and methyl mercury was also measured. PCN was the most effective, doubling the amount of /sup 203/Hg excreted into the bile.

• Research Organization: Univ. of Kansas Medical Center, Kansas City
• OSTI ID: 6265739
• Journal Information: Toxicol. Appl. Pharmacol.; (United States), Journal Name: Toxicol. Appl. Pharmacol.; (United States) Vol. 33:2; ISSN TXAPA
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANESTHETICS
ANIMAL CELLS
ANIMALS
ANTICONVULSANTS
AZINES
BARBITURATES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BILE
BILIARY TRACT
BIOLOGICAL ACCUMULATION
BIOLOGICAL MATERIALS
BODY
BODY FLUIDS
CENTRAL NERVOUS SYSTEM DEPRESSANTS
CHEMICAL ANALYSIS
CLEARANCE
CONCENTRATION RATIO
CONNECTIVE TISSUE CELLS
DAYS LIVING RADIOISOTOPES
DIGESTIVE SYSTEM
DISTRIBUTION
DRUGS
EVEN-ODD NUCLEI
EXCRETION
GLANDS
HEAVY NUCLEI
HETEROCYCLIC COMPOUNDS
HYDROXY COMPOUNDS
HYDROXYPREGNENONE
HYPNOTICS AND SEDATIVES
ISOTOPES
KETONES
LABELLING
LIVER
MAMMALS
MATERIALS
MERCURY 203
MERCURY COMPOUNDS
MERCURY ISOTOPES
NUCLEI
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
ORGANS
PHENOBARBITAL
PLASMA CELLS
PREGNANES
PYRIMIDINES
RADIOACTIVITY
RADIOISOTOPES
RATS
RESPONSE MODIFYING FACTORS
RODENTS
SOMATIC CELLS
STEROIDS
TISSUE DISTRIBUTION
VERTEBRATES