Effects of a major androgen-dependent urinary protein,. alpha. 2u-globulin on the pituitary-gonadal axis and hypothalamic monoamines in adult male mice
The purpose of the present study was to evaluate the effects of alpha-2u-globulin, a sex-dependent male rat urinary protein on pituitary-gonadal functions and hypothalamic monamine contents in male mice. Adult male mice, maintained under standardized laboratory conditions were injected subcutaneously with alpha-2u-globulin or with vehicle daily for 14 days and killed 16 h after the last injection. Plasma levels of luteinizing hormone (LH), follicle-stimulating hormone (FSH), testosterone (T) and testicular levels of T were measured by radioimmunoassays. The concentrations of norepinephrine (NE), dopamine (DA) and serotonin (5-HT) in medial basal hypothalamus (MBH) and anterior hypothalamus (AH) were measured by high performance liquid chromatography. Administration of alpha-2u-globulin led to a significant increase in plasma FSH and LH levels. In the MBH of alpha-2u-globulin treated mice, there were significant elevations of NE, DA and 5-HT contents. In the AH, both DA and 5-HT contents were decreased while NE content remained unaltered.
- OSTI ID:
- 6533216
- Journal Information:
- Life Sciences; (USA), Journal Name: Life Sciences; (USA) Vol. 47:8; ISSN 0024-3205; ISSN LIFSA
- Country of Publication:
- United States
- Language:
- English
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59 BASIC BIOLOGICAL SCIENCES
ADRENAL HORMONES
AMINES
ANDROGENS
ANDROSTANES
ANIMALS
AROMATICS
AUTONOMIC NERVOUS SYSTEM AGENTS
AZAARENES
AZOLES
BIOASSAY
BIOCHEMICAL REACTION KINETICS
BIOLOGICAL FUNCTIONS
BIOSYNTHESIS
BODY
BRAIN
CARDIOTONICS
CARDIOVASCULAR AGENTS
CENTRAL NERVOUS SYSTEM
CHROMATOGRAPHY
DIAGNOSTIC TECHNIQUES
DOPAMINE
DRUGS
ENDOCRINE GLANDS
FSH
FUNCTIONS
GLANDS
GLOBULINS
GLOBULINS-ALPHA
GONADOTROPINS
GONADS
HETEROCYCLIC COMPOUNDS
HORMONES
HYDROXY COMPOUNDS
HYPOTHALAMUS
IMMUNOASSAY
IMMUNOLOGY
INDOLES
ISOTOPE APPLICATIONS
KETONES
KINETICS
LH
LIQUID COLUMN CHROMATOGRAPHY
MAMMALS
MICE
NERVOUS SYSTEM
NEUROREGULATORS
NORADRENALINE
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PEPTIDE HORMONES
PHENOLS
PITUITARY GLAND
PITUITARY HORMONES
POLYPHENOLS
PROTEINS
PYRROLES
RADIOASSAY
RADIOIMMUNOASSAY
RADIOIMMUNODETECTION
RADIOIMMUNOLOGY
RADIOPROTECTIVE SUBSTANCES
REACTION KINETICS
RODENTS
SEPARATION PROCESSES
SEROTONIN
SEX DEPENDENCE
STEROID HORMONES
STEROIDS
SYMPATHOMIMETICS
SYNTHESIS
TESTOSTERONE
TRACER TECHNIQUES
TRYPTAMINES
VERTEBRATES