Rapid postexposure decay of. cap alpha. /sub 2u/-globulin and hyaline droplets in the kidneys of gasoline-treated male rats

Journal Article · Thu Dec 31 23:00:00 EST 1987 · J. Toxicol. Environ. Health; (United States)

DOI:https://doi.org/10.1080/15287398809531149· OSTI ID:7090401

Garg, B D; Olson, M J; Demyan, W F; Roy, A K

Renal ..cap alpha../sub 2u/-globulin content increased to 210% of control within 18 h of a single oral dose of gasoline (2.0 ml/kg) in male rats; maximal levels (320% of control) were attained following gasoline administration for 3 d. Increases in renal ..cap alpha../sub 2u/-globulin caused by gasoline were accompanied by concurrent proliferation of hyaline droplets. However, within 3 d of terminating gasoline administration renal ..cap alpha../sub2u/-globulin content decreased to the same level as that in unexposed rats, although renal hyaline droplet number returned to pretreatment levels somewhat more slowly. The conjoint effect of postexposure recovery and estradiol (an inhibitor of hepatic ..cap alpha../sub 2u/-globulin synthesis) administration was also determined in male rats. On postexposure of 3, 6, and 9, estradiol treatment (1 mg/kg, sc, 4 d, starting on d 9 of gasoline treatment) decreased renal ..cap alpha../sub 2u/-globulin content to 75%, 59%, and 48%, respectively, of that in rats allowed to recover from gasoline with no hormone treatment. Hepatic ..cap alpha../sub 2u/-globulin content in estradiol-treated rats was decreased by 74%, 97%, and 96% at the same intervals. Estradiol treatment during recovery from gasoline also appeared to increase the removal of accumulated hyaline droplets from the renal cortex. Thus, accumulation of ..cap alpha../sub 2u/-globulin-containing hyaline droplets after subacute exposure of male rats to gasoline is rapidly reversible, dependent on continuous exposure to gasoline and maintenance of the normal rate of hepatic ..cap alpha../sub 2u/-globulin synthesis. These results emphasize the dynamic state of renal cortical hyaline droplets and suggest strongly that gasoline hydrocarbons cause hyaline droplet accumulation by prolonging the half-time degradation of ..cap alpha../sub 2u/-globulin.

• Research Organization: General Motors Research Labs., Warren, MI (USA)
• OSTI ID: 7090401
• Journal Information: J. Toxicol. Environ. Health; (United States), Journal Name: J. Toxicol. Environ. Health; (United States) Vol. 24:2; ISSN JTEHD
• Country of Publication: United States
• Language: English

Related Subjects

02 PETROLEUM
020600 -- Petroleum-- Health & Safety
560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOCHEMICAL REACTION KINETICS
BODY
ESTRADIOL
ESTRANES
ESTROGENS
FUELS
GASOLINE
GLOBULINS
HORMONES
HYDROXY COMPOUNDS
KIDNEYS
KINETICS
LIQUID FUELS
MALES
MAMMALS
ORGANIC COMPOUNDS
ORGANS
PATHOLOGICAL CHANGES
PETROLEUM PRODUCTS
PROTEINS
RATS
REACTION KINETICS
RODENTS
STEROID HORMONES
STEROIDS
TOXICITY
VERTEBRATES