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Radioimmunoassay for chlorpromazine in plasma. [/sup 3/H tracer technique]

Journal Article · · Clin. Chem.; (United States)
OSTI ID:6530960
; ; ; ;
A radioimmunoassay for chlorpromazine in plasma is described. The antiserum was obtained by immunizing rabbits with a conjugate of bovine serum albumin and N-(2-carboxyethyl)desmethylchlorpromazine. It is specific for chlorpromazine and its minor active metabolite, N-desmethylchlorpromazine. Other known active or inactive chlorpromazine metabolites and other psychotropic drugs tested do not cross react with the antiserum. Less than 34 pg of the drug can be detected in 200 ..mu..L of plasma. As many as 100 samples can be processed in a day by one technician. Concentrations of chlorpromazine can be measured in 200-..mu..L samples of plasma collected as late as 48 h after a single oral 25-mg dose.
Research Organization:
Health and Welfare Canada, Ottawa, Ont.
OSTI ID:
6530960
Journal Information:
Clin. Chem.; (United States), Journal Name: Clin. Chem.; (United States) Vol. 25:1; ISSN CLCHA
Country of Publication:
United States
Language:
English

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Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
AMINES
AZINES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BLOOD
BLOOD PLASMA
BODY FLUIDS
CHLORPROMAZINE
DRUGS
HETEROCYCLIC COMPOUNDS
HYDROGEN ISOTOPES
IMMUNE SERUMS
ISOTOPE APPLICATIONS
ISOTOPES
LIGHT NUCLEI
METABOLITES
NUCLEI
ODD-EVEN NUCLEI
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC SULFUR COMPOUNDS
PHENOTHIAZINES
PSYCHOTROPIC DRUGS
RADIOASSAY
RADIOIMMUNOASSAY
RADIOISOTOPES
TRACER TECHNIQUES
TRANQUILIZERS
TRITIUM
YEARS LIVING RADIOISOTOPES