Early dynamic bone-imaging as an indicator of osseous blood flow and factors affecting the uptake of /sup 99m/Tc hydroxymethylene diphosphonate in healing bone

Journal Article · Sat Jun 01 04:00:00 EDT 1985 · J. Bone Jt. Surg., Am. Vol.; (United States)

OSTI ID:6527960

Nutton, R W; Fitzgerald, Jr, R H; Kelly, P J

The authors determined the uptake of /sup 99m/Tc-labeled hydroxymethylene diphosphonate in a surgically created defect in the canine tibia with early dynamic and delayed static bone scans. The defect consisted of a cortical bone window, ten by five millimeters, centered over the middle of the tibia. The dynamic bone scans consisted of sixty one-second images of the tibia, recorded immediately after the injections of /sup 99m/Tc, and the static scans were single forty-five-minute uptake images of the tibia. These were performed and the dogs were killed at seven, fourteen, and twenty-eight days postoperatively. The dynamic scans detected the postoperative increase in tibial blood flow because the values calculated from these scans demonstrated a significant linear relationship to tibial blood flow determined with radioactive microspheres (r = 0.76, p less than 0.001). The increased uptake of 99mTc in the cortical defect that was detected with static scans was attributable not only to the increased blood flow but also to uptake by immature bone. Early dynamic bone-imaging increases the versatility of bone scintigraphy. The significant correlation between the dynamic scans and bone blood flow suggests that this non-invasive technique can provide a quantitative comparison of changes in regional blood flow in bone.

• OSTI ID: 6527960
• Journal Information: J. Bone Jt. Surg., Am. Vol.; (United States), Journal Name: J. Bone Jt. Surg., Am. Vol.; (United States) Vol. 5; ISSN JBJSA
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BLOOD FLOW
BODY
COUNTING TECHNIQUES
DIAGNOSTIC TECHNIQUES
DOGS
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
MAMMALS
MICROSPHERES
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANIC PHOSPHORUS COMPOUNDS
ORGANS
PHOSPHONATES
RADIOISOTOPE SCANNING
RADIOISOTOPES
SCINTISCANNING
SKELETON
TECHNETIUM 99
TECHNETIUM ISOTOPES
TIBIA
TRACER TECHNIQUES
VERTEBRATES
YEARS LIVING RADIOISOTOPES