Tc-99m HMDP (Hydroxymethylene diphosphonate): a radiopharmaceutical for skeletal and acute myocardial infarct imaging. I. synthesis and distribution in animals. [Rats, dogs]

Conference · Wed Oct 01 04:00:00 EDT 1980 · J. Nucl. Med.; (United States)

OSTI ID:6861338

Bevan, J A; Tofe, A J; Benedict, J J; Francis, M D; Barnett, B L

Technetium-99m hydroxymethylene diphosphonate (Tc-99m HMDP) is a new diphosphonate skeletal imaging agent. Animal studies show that Tc-99m HMDP has a higher uptake on bone and a more rapid clearance from the blood than any of the three technetium-labeled bone imaging agents in current use: Tc-99m methylene diphosphonate (MDP), Tc-99m (1-hydroxyethylidene) diphosphonate (HEDP), and Tc-99m pyrophosphate (PPi). On the basis of these animal studies, Tc-99m HMDP is a highly promising candidate for skeletal imaging.

• Research Organization: Procter and Gamble Co., Cincinnati, OH
• OSTI ID: 6861338
• Conference Information: Journal Name: J. Nucl. Med.; (United States) Journal Volume: 21:10
• Country of Publication: United States
• Language: English

Related Subjects

38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
400702* -- Radiochemistry & Nuclear Chemistry-- Properties of Radioactive Materials
550601 -- Medicine-- Unsealed Radionuclides in Diagnostics
560172 -- Radiation Effects-- Nuclide Kinetics & Toxicology-- Animals-- (-1987)
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL ACCUMULATION
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BLOOD-PLASMA CLEARANCE
BODY
BODY FLUIDS
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
CHEMICAL PREPARATION
CLEARANCE
COUNTING TECHNIQUES
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DIGESTIVE SYSTEM
DISEASES
DOGS
DRUGS
EXCRETION
FEMUR
GLANDS
HEART
HOURS LIVING RADIOISOTOPES
HYDROXY COMPOUNDS
INTERMEDIATE MASS NUCLEI
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
KIDNEYS
LABELLED COMPOUNDS
LIVER
MAMMALS
MATERIALS
MYOCARDIAL INFARCTION
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANIC PHOSPHORUS COMPOUNDS
ORGANS
OXYGEN COMPOUNDS
PHOSPHATES
PHOSPHONATES
PHOSPHORUS COMPOUNDS
RADIOACTIVE MATERIALS
RADIOISOTOPE SCANNING
RADIOISOTOPES
RADIONUCLIDE KINETICS
RADIOPHARMACEUTICALS
RATS
RODENTS
SCINTISCANNING
SKELETON
SYNTHESIS
TECHNETIUM 99
TECHNETIUM COMPOUNDS
TECHNETIUM ISOTOPES
TECHNETIUM PHOSPHATES
TRANSITION ELEMENT COMPOUNDS
URINE
VERTEBRATES
WASTES
YEARS LIVING RADIOISOTOPES