Blood flow and bone uptake of /sup 99m/Tc-labeled methylene diphosphonate

Journal Article · Sun Jan 01 04:00:00 EST 1984 · J. Orth. Res.; (United States)

OSTI ID:5888485

Riggs, S A; Wood, M B; Cooney, W P; Kelly, P J

In mature dogs with comparable levels of bone remodeling, we produced either increased (with adenosine triphosphate) or decreased (with epinephrine) blood flow to one hindlimb. In 13 dogs (five control, four with increased flow, and four with decreased flow), we compared uptake, at 3 h after injection of radiolabeled diphosphonate in the mid-tibia, with blood flow as determined by microspheres. Blood flow was determined with /sup 85/Sr-labeled microspheres, and determination of uptake of /sup 99m/Tc methylene diphosphonate (/sup 99m/Tc-MDP) was by a gamma detector. There was a linear relationship between changes in diphosphonate uptake and changes in blood flow at decreased and normal flows; however, at high flows the relationship was nonproportional, indicating a disproportionately slower increase in /sup 99m/Tc-MDP uptake with increasing blood flow. In six dogs an initial 1-h uptake curve of /sup 99m/Tc-MDP was determined in both control and experimental limbs under states of increased and decreased blood flow. The 30-min uptake value, 60-min uptake value, area under the curve, and the slope of the curve were related to flow as determined by microspheres. The data are consistent with the hypothesis that deposition of bone-concentrating isotopes such as /sup 99m/Tc-MDP is partly controlled by blood flow; at supranormal and normal flows tracer uptake is closely related to blood flow, but at supranormal flow rates it is not and appears to be diffusion limited.

• Research Organization: Mayo Clinic, Rochester, MN
• OSTI ID: 5888485
• Journal Information: J. Orth. Res.; (United States), Journal Name: J. Orth. Res.; (United States) Vol. 1:3; ISSN JORED
• Country of Publication: United States
• Language: English

Related Subjects

551001* -- Physiological Systems-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ALKALINE EARTH ISOTOPES
ANIMALS
ATP
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BLOOD FLOW
BODY
CARDIOVASCULAR SYSTEM
DAYS LIVING RADIOISOTOPES
DOGS
DYNAMIC FUNCTION STUDIES
ELECTRON CAPTURE RADIOISOTOPES
ESTERS
EVEN-ODD NUCLEI
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
LABELLED COMPOUNDS
MAMMALS
MICRORADIOGRAPHY
MICROSPHERES
NUCLEI
NUCLEOTIDES
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANIC PHOSPHORUS COMPOUNDS
ORGANS
PHOSPHONIC ACID ESTERS
RADIOISOTOPES
SKELETON
STRONTIUM 85
STRONTIUM ISOTOPES
TECHNETIUM 99
TECHNETIUM ISOTOPES
TRACER TECHNIQUES
UPTAKE
VERTEBRATES
YEARS LIVING RADIOISOTOPES