Dynamic radioisotope bone imaging as a noninvasive indicator of canine tibial blood flow

Journal Article · Sun Jan 01 04:00:00 EST 1984 · J. Orth. Res.; (United States)

DOI:https://doi.org/10.1002/jor.1100020111· OSTI ID:5827933

Nutton, R W; Fitzgerald, Jr, R H; Brown, M L; Kelly, P J

The relative values of dynamic and static bone imaging with hydroxymethylenediphosphonate technetium /sup 99m/ (/sup 99m/Tc HDP) as an indicator of bone blood flow was investigated in the tibia of mature dogs. The dynamic bone scan consisted of 60 1-s images formed after the intravenous injection of /sup 99m/Tc HDP, and the static bone scan was a 45-min uptake image. Blood flow to the tibia was determined by using radioactively labeled microspheres. Studies were carried out in control dogs, in dogs in which blood flow was increased in one leg with ATP, and in dogs in which blood flow was decreased in one leg with norepinephrine. A significant linear relationship between the dynamic scan values and bone blood flow was found at a wide range of blood flow rates. When blood flow increased by more than 50%, the effects of diffusion limitation were seen in the static scans: increase in tracer uptake was disproportionately small for a significant increase in blood flow. There is no method currently available for estimating bone blood flow by a noninvasive technique. The method described here may be useful for providing a semiquantitative measure of bone blood flow. This improved versatility of bone imaging may have a role in the management of osteomyelitis or complicated fractures, or in assessing the viability of vascularized bone grafts.

• Research Organization: Mayo Clinic, Rochester, MN
• OSTI ID: 5827933
• Journal Information: J. Orth. Res.; (United States), Journal Name: J. Orth. Res.; (United States) Vol. 2:1; ISSN JORED
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ADP
ADRENAL HORMONES
ANIMALS
ATP
AUTONOMIC NERVOUS SYSTEM AGENTS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BLOOD FLOW
BODY
CARDIOTONICS
CARDIOVASCULAR AGENTS
COUNTING TECHNIQUES
DOGS
DRUGS
DYNAMIC FUNCTION STUDIES
HORMONES
HOURS LIVING RADIOISOTOPES
INJECTION
INTAKE
INTERMEDIATE MASS NUCLEI
INTRAVENOUS INJECTION
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
MEASURING METHODS
MICROSPHERES
NEUROREGULATORS
NORADRENALINE
NUCLEI
NUCLEOTIDES
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANIC PHOSPHORUS COMPOUNDS
ORGANS
PHOSPHONATES
RADIOISOTOPE SCANNING
RADIOISOTOPES
SKELETON
STEROID HORMONES
SYMPATHOMIMETICS
TECHNETIUM 99
TECHNETIUM ISOTOPES
TIBIA
VERTEBRATES
YEARS LIVING RADIOISOTOPES