Endoscopic measurements of canine colonic mucosal blood flow using hydrogen gas clearance

Journal Article · Wed Apr 01 04:00:00 EST 1987 · Gastroenterology; (United States)

OSTI ID:6525125

Soybel, D I; Wan, Y L; Ashley, S W; Yan, Z Y; Ordway, F S; Cheung, L Y

We have examined the feasibility of hydrogen (H/sub 2/) clearance for endoscopic measurements of colonic mucosal blood flow in anesthetized dogs. In 6 animals, measurements of H2 clearance did not differ significantly in different regions of the sigmoid colon and they were highly reproducible on different days. In a total of 12 dogs, measurements of H2 clearance correlated closely with those obtained using radioactive microspheres under resting conditions and, in 4 dogs, during infusion of vasopressin. In 8 dogs, ligation of the major arteries supplying the sigmoid colon resulted in an acute 60% decrease in sigmoid mucosal blood flow; however, in 5 animals that survived the procedure, mucosal blood flow returned nearly to control levels as early as 3 days after operation. Endoscopic H/sub 2/ clearance thus appears to be feasible for measuring mucosal blood flow in the colon. Serial measurements of H/sub 2/ clearance may prove useful in characterizing the role of mucosal blood flow in the pathogenesis of various forms of human colonic disease.

• Research Organization: Washington Univ. School of Medicine, St. Louis, MO
• OSTI ID: 6525125
• Journal Information: Gastroenterology; (United States), Journal Name: Gastroenterology; (United States) Vol. 4; ISSN GASTA
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMALS
BLOOD FLOW
BODY
CLEARANCE
COMPARATIVE EVALUATIONS
DIGESTIVE SYSTEM
DOGS
ELEMENTS
GADOLINIUM
GASTROINTESTINAL TRACT
HYDROGEN
INTESTINES
ISOTOPES
LARGE INTESTINE
MAMMALS
MEASURING METHODS
MEMBRANES
METALS
MICROSPHERES
MUCOUS MEMBRANES
NONMETALS
ORGANS
RADIOISOTOPES
RARE EARTHS
TIN
VERTEBRATES