Canine gastric mucosal vasodilation with prostaglandins and histamine analogs

Journal Article · Fri Oct 01 04:00:00 EDT 1982 · Dig. Dis. Sci.; (United States)

DOI:https://doi.org/10.1007/BF01316568· OSTI ID:6578749

Gerber, J G; Nies, A S

The effect of direct intragastric artery infusion of prostaglandins E2 and I2, arachidonic acid, dimaprit (histamine H2 agonist), and 2',2'-pyridylethylamine (histamine H1 agonist) on gastric mucosal blood flow was examined in dogs to elucidate the relationship between gastric secretory state and mucosal blood flow in dogs. These compounds were chosen because of their diverse effect on gastric acid secretion. Gastric fundus blood flow was measured both electromagnetically with a flow probe around the left gastric artery which supplies the fundus almost exclusively, and by the radioactive microsphere technique. Intraarterial infusion of all the compounds resulted in gastric mucosal vasodilation even though PGE2, PGI2, and arachidonic acid inhibit gastric acid secretion, dimaprit stimulated gastric acid secretion, and 2',2'-pyridylethylamine does not affect gastric acid secretion. There was total agreement in the blood flow measurements by the two different techniques. Our data suggest that gastric acid secretion and gastric vasodilation are independently regulated. In addition, the validity of the studies in which the aminopyrine clearance indicates that prostaglandins are mucosal vasoconstrictors needs to be questioned because of the reliance of those measurements on the secretory state of the stomach.

• Research Organization: Division of Clinical Pharmacology, University of Colorado Health Sciences Center, Denver
• OSTI ID: 6578749
• Journal Information: Dig. Dis. Sci.; (United States), Journal Name: Dig. Dis. Sci.; (United States) Vol. 27:10; ISSN DDSCD
• Country of Publication: United States
• Language: English

Related Subjects

551001* -- Physiological Systems-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
AMINES
ANIMALS
ARACHIDONIC ACID
AZOLES
BIOLOGICAL EFFECTS
BLOOD FLOW
BODY
CARBOXYLIC ACIDS
DIGESTIVE SYSTEM
DOGS
GASTROINTESTINAL TRACT
HETEROCYCLIC COMPOUNDS
HISTAMINE
IMIDAZOLES
ISOTOPE APPLICATIONS
MAMMALS
MEMBRANES
MICROSPHERES
MONOCARBOXYLIC ACIDS
MUCOUS MEMBRANES
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PROSTAGLANDINS
STOMACH
TRACER TECHNIQUES
VASODILATION
VERTEBRATES