Mesenteric vascular reactivity to histamine receptor agonists and antagonists. [Dogs]

Journal Article · Fri May 01 00:00:00 EDT 1981 · Dig. Dis. Sci.; (United States)

DOI:https://doi.org/10.1007/BF01313587· OSTI ID:5658679

Walus, K M; Fondacaro, J D; Jacobson, E D

Response patterns of intestinal blood flow, oxygen extraction and consumption, blood flow distribution, and motility were assessed during intraarterial infusions of histamine, histamine after H1 or H2 blockade, dimaprit or dimaprit after H2 blockade. Histamine produced an initial peak response of blood flow with a slow decrease thereafter. Oxygen extraction was evenly depressed throughout the infusion, and oxygen consumption increased at the beginning. All initial responses were blocked by tripelennamine. Ranitidine, a new H2 antagonist, accelerated the decay of all responses. Dimaprit produced effects identical to those of histamine after tripelennamine. Distribution of blood flow was unchanged at the beginning of histamine infusion, but subsequently showed a shift to muscularis which was blocked by tripelennamine. Histamine usually stimulated intestinal contractions and this effect was abolished by tripelennamine. Thus, H1 stimulation, besides producing an initial vasodilation, increases oxygen uptake and redistributes flow to the muscularis.

• OSTI ID: 5658679
• Journal Information: Dig. Dis. Sci.; (United States), Journal Name: Dig. Dis. Sci.; (United States) Vol. 26:5; ISSN DDSCD
• Country of Publication: United States
• Language: English

Related Subjects

551000* -- Physiological Systems
59 BASIC BIOLOGICAL SCIENCES
AMINES
ANIMALS
AZOLES
BLOOD FLOW
BODY
CARDIOVASCULAR AGENTS
DIGESTIVE SYSTEM
DISTRIBUTION
DOGS
DOSE-RESPONSE RELATIONSHIPS
DRUGS
ELEMENTS
GASTROINTESTINAL TRACT
HETEROCYCLIC COMPOUNDS
HISTAMINE
IMIDAZOLES
INTESTINES
MAMMALS
METABOLISM
NONMETALS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
OXYGEN
RECEPTORS
TISSUE DISTRIBUTION
VERTEBRATES