Measurement of gastric mucosal blood flow in dogs by the /sup 99m/Tc 4-methylaminophenazone clearance technique

Journal Article · Thu Jul 01 04:00:00 EDT 1982 · Gastroenterology; (United States)

OSTI ID:6709987

Doebroente, Z; Lang, J; Sagi, I; Varro, V

In anesthetized dogs, correlation was found between the /sup 99m/Tc 4-methylaminophenazone and aminopyrine clearance measured in the same animal after administration of the gastric secretory stimulants vasopressin or glucagon. Similar correlation was observed between the /sup 99m/Tc 4-methylaminophenazone and /sup 14/C aminopyrine clearance during histamine administration. The clearance values were always corrected by the actual degree of dissociation of the radioactive molecules. The results suggest that /sup 99m/Tc 4-methylaminophenazone is suitable to study circulatory changes in human gastric mucosa. Advantages of this compound include a much lower dose of radiation absorbed by the patient and his surroundings, a simplified measurement technique, and considerably reduced expenses.

• Research Organization: First Department of Internal Medicine, University Medical School, Szeged, Hungary
• OSTI ID: 6709987
• Journal Information: Gastroenterology; (United States), Journal Name: Gastroenterology; (United States) Vol. 83:1 Pt 2; ISSN GASTA
• Country of Publication: United States
• Language: English

Related Subjects

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
400102 -- Chemical & Spectral Procedures
550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
551001 -- Physiological Systems-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
AMINES
ANIMALS
AZOLES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BLOOD FLOW
CARBON 14 COMPOUNDS
CHEMICAL ANALYSIS
COMPARATIVE EVALUATIONS
DIGESTIVE SYSTEM
DOGS
DOSES
GASTROINTESTINAL TRACT
GLUCAGON
HETEROCYCLIC COMPOUNDS
HISTAMINE
HORMONES
HOURS LIVING RADIOISOTOPES
IMIDAZOLES
INTERMEDIATE MASS NUCLEI
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
LABELLED COMPOUNDS
MAMMALS
MEASURING METHODS
MEMBRANES
MUCOUS MEMBRANES
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PEPTIDE HORMONES
PEPTIDES
PHYSIOLOGY
PITUITARY HORMONES
POLYPEPTIDES
PROTEINS
QUANTITATIVE CHEMICAL ANALYSIS
RADIATION DOSES
RADIOISOTOPES
TECHNETIUM 99
TECHNETIUM ISOTOPES
VASOPRESSIN
VERTEBRATES
YEARS LIVING RADIOISOTOPES