In vivo method for the evaluation of catheter thrombogenicity
Journal Article
·
· J. Biomed. Mater. Res.; (United States)
A new method has been developed to evaluate the relative thrombogenicity of vascular catheters. The technique provides a means to quantitatively differentiate between catheters made from different polymeric materials. Autologous In-111 labeled platelets were infused into a dog model and catheters were then inserted into the external jugular vein of the dog. The neck region was scanned using gamma camera imaging. Comparisons between catheter materials were made using computer generated uptake slopes during the first 40 min of the scan. In addition to scintigraphy, visual assessment of thrombus deposition, thrombus weight, platelet deposition, and scanning electron microscopy were used to validate the technique. Poly(vinyl chloride), polyurethane, heparinized polyurethane, and silicone catheter materials were tested. It was found that heparinized polyurethane was the least thrombogenic of all materials evaluated.
- Research Organization:
- Wright State School of Medicine, Dayton, OH
- OSTI ID:
- 6524042
- Journal Information:
- J. Biomed. Mater. Res.; (United States), Journal Name: J. Biomed. Mater. Res.; (United States) Vol. 1; ISSN JBMRB
- Country of Publication:
- United States
- Language:
- English
Similar Records
The dynamics of platelet thrombus formation rate, thrombus retention time, and rate of embolization on a control and heparin bonded polyurethane angio-catheter
Heparin-Coated Angiographic Catheters: An In Vivo Comparison of Three Coating Methods with Different Heparin Release Profiles
Evaluation of catheter thrombogenicity in vivo with indium-labeled platelets
Journal Article
·
Sun Jul 01 00:00:00 EDT 1990
· ASAIO Transactions (American Society for Artificial Internal Organs); (USA)
·
OSTI ID:6273322
Heparin-Coated Angiographic Catheters: An In Vivo Comparison of Three Coating Methods with Different Heparin Release Profiles
Journal Article
·
Wed Sep 15 00:00:00 EDT 2004
· Cardiovascular and Interventional Radiology
·
OSTI ID:21088226
Evaluation of catheter thrombogenicity in vivo with indium-labeled platelets
Journal Article
·
Mon Mar 31 23:00:00 EST 1980
· Radiology; (United States)
·
OSTI ID:5179986
Related Subjects
550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMALS
BETA DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BLOOD PLATELETS
BLOOD VESSELS
BODY
BODY FLUIDS
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
COMPARATIVE EVALUATIONS
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DISEASES
DOGS
ELECTRON CAPTURE RADIOISOTOPES
ELECTRON MICROSCOPY
IN VIVO
INDIUM 111
INDIUM ISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
MATERIALS
MEDICAL SUPPLIES
MICROSCOPY
MINUTES LIVING RADIOISOTOPES
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANIC SILICON COMPOUNDS
ORGANS
POLYMERS
RADIOISOTOPE SCANNING
RADIOISOTOPES
SCANNING ELECTRON MICROSCOPY
SCINTISCANNING
SILICONES
SILOXANES
THROMBOSIS
VASCULAR DISEASES
VERTEBRATES
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMALS
BETA DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BLOOD PLATELETS
BLOOD VESSELS
BODY
BODY FLUIDS
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
COMPARATIVE EVALUATIONS
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DISEASES
DOGS
ELECTRON CAPTURE RADIOISOTOPES
ELECTRON MICROSCOPY
IN VIVO
INDIUM 111
INDIUM ISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
MATERIALS
MEDICAL SUPPLIES
MICROSCOPY
MINUTES LIVING RADIOISOTOPES
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANIC SILICON COMPOUNDS
ORGANS
POLYMERS
RADIOISOTOPE SCANNING
RADIOISOTOPES
SCANNING ELECTRON MICROSCOPY
SCINTISCANNING
SILICONES
SILOXANES
THROMBOSIS
VASCULAR DISEASES
VERTEBRATES