The dynamics of platelet thrombus formation rate, thrombus retention time, and rate of embolization on a control and heparin bonded polyurethane angio-catheter

Journal Article · Sun Jul 01 04:00:00 EDT 1990 · ASAIO Transactions (American Society for Artificial Internal Organs); (USA)

OSTI ID:6273322

Dewanjee, M K; Rowland, S M; Kapadvanjwala, M; Hellman, R L; MacGregor, D C; Serafini, A N; Palatianos, G M; Georgiou, M F; Eckstein, E C; Sfakianakis, G N ^[1]

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1. Univ. of Miami, FL (USA)

The dynamics of platelet deposition and embolization from control and heparin bonded polyurethane catheters (CPC and HBPC) was evaluated with In-111 labeled autologous platelets (IN-PLT) and a computerized gamma camera (CGC). Ten non-heparinized dogs (18-25 kg) were catheterized in both femoral arteries with 10 cm of CPC and HBPC (5 Fr., Cordis) 24 hr after injection of 300-420 microCi of In-PLT, and imaged for 3 hr with the computerized gamma camera. The regional platelet deposition curves (RPDC) indicated multiple peaks and valleys; the curves were analyzed for early rate of thrombus formation (upswing), thrombus retention time (full width at half maxima of the RPDC-peak), and rate of embolization (downswing) on both catheters. The four parameters (mean +/- SD) of thrombosis on catheters and integral of the radioactivity time curve for the 3 hr duration of imaging were calculated from normalized counts/sec. The rate of thrombus formation and rate of embolization are higher for the control than HBPC, suggesting that heparin-bonding decreases the early rate of thrombosis and embolization. The thrombus adhesivity and retention time appear shorter for the control catheter, indicating that the control thrombogenic catheter forms multiple thrombi and emboli than HBPC. The integral appears larger for the control catheter than HBPC. In vivo (dynamic) studies, in vitro studies, and critical analyses of the radioactivity time curve were essential for complete evaluation of thrombogenicity of catheters and other cardiovascular prostheses.

• OSTI ID: 6273322
• Journal Information: ASAIO Transactions (American Society for Artificial Internal Organs); (USA), Journal Name: ASAIO Transactions (American Society for Artificial Internal Organs); (USA) Vol. 36:3; ISSN ASATE; ISSN 0889-7190
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMALS
BETA DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BLOOD COAGULATION
BLOOD PLATELETS
BLOOD VESSELS
BODY
BODY FLUIDS
CAMERAS
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
DAYS LIVING RADIOISOTOPES
DISEASES
DOGS
DYNAMIC FUNCTION STUDIES
ELECTRON CAPTURE RADIOISOTOPES
GAMMA CAMERAS
IMAGE PROCESSING
INDIUM 111
INDIUM ISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
MATERIALS
MEDICAL SUPPLIES
MINUTES LIVING RADIOISOTOPES
NUCLEI
ODD-EVEN NUCLEI
ORGANS
PROCESSING
PROSTHESES
RADIOISOTOPES
THROMBOSIS
VASCULAR DISEASES
VERTEBRATES