Heparin-Coated Angiographic Catheters: An In Vivo Comparison of Three Coating Methods with Different Heparin Release Profiles

Journal Article · Wed Sep 15 04:00:00 EDT 2004 · Cardiovascular and Interventional Radiology

DOI:https://doi.org/10.1007/S00270-003-4035-5· OSTI ID:21088226

Lee, Kyoung Ho; Byun, Youngro ^[1]; Moon, Hyun Tae ^[2]; Yoon, Chang Jin ^[3]; Kim, Seung Ja; Choi, Byung Ihn ^[4]

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1. Kwangju Institute of Science and Technology, Department of Materials Science and Engineering (Korea, Republic of)
2. Mediplex Co., Commercialization Blg, Research and Development Division (Korea, Republic of)
3. Seoul National University Bundang Hospital, Department of Radiology (Korea, Republic of)
4. Seoul National University College of Medicine, 28 Yongon-dong, Chongno-gu, Seoul, 110-744, Korea. Institute of Radiation Medicine, Seoul National University College of Medicine, Clinical Research Institute, Seoul National University Hospital , Department of Radiology (Korea, Republic of)

We evaluated in vivo anti-thrombogenic effects of three different heparin-coated angiographic catheters with different heparin release profiles. Three different types of heparin-coated 5 French angiographic catheters (rapidly-heparin-releasing, slowly-heparin-releasing, and heparin-adherent catheters) were prepared by coating amphiphilic or hydrophobic heparin derivatives in order to regulate heparin elution. After incubation time of 30 minutes in the arteries of dogs, the amount of thrombus deposition, measured as dry weight, was compared in 10 sets of the three heparin-coated catheters and a non-coated catheter used as control. The surface morphology of catheters after their withdrawal was studied by scanning electron microscopy. The amount of thrombus deposition on the non-coated catheter (374.6 {+-} 11.6 mg, mean {+-} SD) was significantly larger than those on the rapidly-heparin-releasing (52.0 {+-} 12.6), slowly-heparin-releasing (70.4 {+-} 23.1), and heparin-adherent catheters (103.7 {+-} 39.9) (p < 0.001, each). The thrombus weights in the three heparin-coated catheters were not statistically different. The scanning electron microscopy showed crusts on the catheter surface, which were thickest in the non-coated catheters. We concluded that the thrombus formation inside a catheter is significantly decreased if the catheter is treated with any of the three heparin-coating methods used in this study. The in vivo anti-thrombogenic effects of these coating methods are not significantly different despite their different heparin release profiles.

• OSTI ID: 21088226
• Journal Information: Cardiovascular and Interventional Radiology, Journal Name: Cardiovascular and Interventional Radiology Journal Issue: 5 Vol. 27; ISSN 0174-1551; ISSN CAIRDG
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
ARTERIES
DOGS
HEPARIN
IN VIVO
MORPHOLOGY
SCANNING ELECTRON MICROSCOPY