Evaluation of catheter thrombogenicity in vivo with indium-labeled platelets

Journal Article · Tue Apr 01 04:00:00 EST 1980 · Radiology; (United States)

DOI:https://doi.org/10.1148/radiology.135.1.6767268· OSTI ID:5179986

Lipton, M J ^[1]; Doherty, P W; Goodwin, D A; Bushberg, G T; Prager, R; Meares, C F

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1. Univ. of California, San Francisco

Platelets labeled with a lipid-soluble indium-111 8-hydroxyquinoline (oxine) complex were evaluated as an agent to measure the rate and degree of in vivo platelet accumulation on catheters. Polyethylene catheters and Teflon-coated guidewires were inserted into the femoral arteries or veins of dogs that had been injected with indium-labeled platelets. The catheters were passed to either the abdominal aorta or inferior vena cava and left in situ for 30 minutes to three hours. Images were obtained every five minutes with a gamma camera. This labeling technique is reproducible, allow multiple testing with a single preparation, and is relatively noninvasive. The results are easily quantitated to allow testing of different materials and coatings.

• OSTI ID: 5179986
• Journal Information: Radiology; (United States), Journal Name: Radiology; (United States) Vol. 135:1; ISSN RADLA
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
550901 -- Pathology-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMALS
ARTERIES
AZINES
BETA DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BLOOD PLATELETS
BLOOD VESSELS
BODY
BODY FLUIDS
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
COUNTING TECHNIQUES
DATA
DATA FORMS
DAYS LIVING RADIOISOTOPES
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DIAGRAMS
DISEASES
DOGS
ELECTRON CAPTURE RADIOISOTOPES
EVALUATION
EXPERIMENTAL DATA
FLUORINATED ALIPHATIC HYDROCARBONS
GRAPHS
HALOGENATED ALIPHATIC HYDROCARBONS
HETEROCYCLIC COMPOUNDS
HYDROXY COMPOUNDS
INDIUM 111
INDIUM ISOTOPES
INFORMATION
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
MATERIALS
MINUTES LIVING RADIOISOTOPES
NUCLEI
NUMERICAL DATA
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANIC FLUORINE COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC POLYMERS
ORGANS
OXINE
PETROCHEMICALS
PETROLEUM PRODUCTS
PLASTICS
POLYETHYLENES
POLYMERS
POLYOLEFINS
POLYTETRAFLUOROETHYLENE
PYRIDINES
QUINOLINES
RADIOISOTOPE SCANNING
RADIOISOTOPES
SCINTISCANNING
TEFLON
THROMBOSIS
TIME DEPENDENCE
TUBES
VEINS
VERTEBRATES