Effect of starvation on /sup 65/Zn tissue distribution and excretion by rats

Conference · Mon Jun 01 04:00:00 EDT 1981 · Trace Subst. Environ. Health; (United States)

OSTI ID:6521460

Menczel, J; Lender, M; Spencer, H

The effect of starvation on the excretion and tissue distribution of zinc in rats was investigated by using /sup 65/ZnCl/sub 2/(6..mu..c) as the tracer intraperitoneally. The control group was fed a semi-liquid diet and the starvation group received distilled water only. Complete urine and stool collections were obtained. After 4 days of starvation the rats lost 21% of the initial weight vs. 6.8% for the control animals. Fecal /sup 65/Zn excretion was higher than urinary excretion in both groups; however, the fecal /sup 65/Zn of the starved rats was lower than that of the control group (30.5% vs. 36.8%, respectively). The /sup 65/Zn concentration per ml urine of the starved rats was similar or even higher than that of the control group; however, the total urinary /sup 65/Zn excretion was lower during starvation, 0.34% of the dose, due to the lower urine volume, vs 0.99% for the control group. The rats were sacrificed on day 4 and samples of blood, multiple soft tissues and bone were obtained. The /sup 65/Zn uptake was higher in all soft tissues of the starved rats than of the control rats, except for the pancreas. The /sup 65/Zn uptake in bone was similar in both groups.

• Research Organization: Veterans Administration Hospital, Hines, IL
• OSTI ID: 6521460
• Report Number(s): CONF-8106251-
• Conference Information: Journal Name: Trace Subst. Environ. Health; (United States) Journal Volume: 15
• Country of Publication: United States
• Language: English

Related Subjects

550501 -- Metabolism-- Tracer Techniques
551001 -- Physiological Systems-- Tracer Techniques
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BIOLOGICAL LOCALIZATION
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BODY
BODY FLUIDS
CHLORIDES
CHLORINE COMPOUNDS
CLEARANCE
DAYS LIVING RADIOISOTOPES
DIGESTIVE SYSTEM
DISTRIBUTION
ELECTRON CAPTURE RADIOISOTOPES
ELEMENTS
ENDOCRINE GLANDS
EVEN-ODD NUCLEI
EXCRETION
FASTING
FECES
GLANDS
HALIDES
HALOGEN COMPOUNDS
INTERMEDIATE MASS NUCLEI
ISOTOPE APPLICATIONS
ISOTOPES
MAMMALS
MATERIALS
METABOLISM
METALS
NUCLEI
ORGANS
PANCREAS
RADIOISOTOPES
RADIONUCLIDE KINETICS
RATS
RODENTS
SKELETON
TISSUE DISTRIBUTION
TRACER TECHNIQUES
URINE
VERTEBRATES
WASTES
ZINC
ZINC 65
ZINC CHLORIDES
ZINC COMPOUNDS
ZINC HALIDES
ZINC ISOTOPES