Metabolism of $sup 57$Co-methylcobalamine i rat and guinea pig

Journal Article · Fri Dec 01 04:00:00 EST 1972 · Chem. Pharm. Bull. (Tokyo), v. 20, no. 12, pp. 2561-2569

OSTI ID:4360609

Kinoshita, K; Fujita, T

The metabolic fate of /sup 57/Co-methylcobalamine after oral or intraperitoneal administration to rats and guinea pigs (25 mu g/kg) was studied. From fecal excretion test, the intestinal absorption of /sup 57/Co-methyl- cobalamine seems to be less than 5% of the dose, and the time course of fecal excretion was different in both species. The fecal excretion in guinea pig was slower and more continuous than in rat. The urinary excretion of radioactivity after intraperitoneal administration was lower in rat 141% of dose during the first 24 hr) than in guinea pig 168%), and the main excretion form in urine was / sup 57/Co-methylcobalamine itself in both species. /sup 57/Co-methylcobalamine might be stable in the intestinal tract and transferred through the intestinal wall in unchanged form. Tissue distribution of radioactivity after intraperitoneal administration was higher in rat than in guinea - generally, and the highest uptake in rat was found in the kidney, while the trend of higher uptake in guinea pig was found in the liver. The biological-conversion of /sup 57/Co-methylcobalamine incorporated in liver and kidney into other cobamide analogs was studied, and it was evident that /sup 57/Co-methylcobalamine was transformed to 5, 6-dimethylbenzimidazolylcobamide coenzyme and hydroxocobalamine in both species. (auth)

• Research Organization: Eisai Co. Ltd., Tokyo
• NSA Number: NSA-29-010564
• OSTI ID: 4360609
• Journal Information: Chem. Pharm. Bull. (Tokyo), v. 20, no. 12, pp. 2561-2569, Journal Name: Chem. Pharm. Bull. (Tokyo), v. 20, no. 12, pp. 2561-2569; ISSN CPBTA
• Country of Publication: Japan
• Language: English

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