EFFECT OF SOY-FLOUR DIET AND OTHER AGENTS ON EXCRETION OF I131 AFTER USE OF LABELED THYROXINE IN THE RAT
The fecal and urinary excretion of I¹³¹ after injection of radioactive thyroxine was measured in rats fed diets of soy flour, starch-casein, standard laboratory chow, and the Remington mixture. Rats fed the soy-flour, starch-casein, and Remington diets excreted less I¹³¹ in the feces than did control rats. No difference was present in the biliary excretion of I¹³¹ or in the transformation of I¹³¹-thyroxi ne by the intestinal contents. The weight of stools of the rats consuming the test diets was one-half that of the control group. The thyroidal uptake of I¹³¹ and the serum proteinbound iodine (PBI) were low in the rats fed soy-flour diets. The thyroid showed a small increase in weight, but the gland exhibited less cellular activity as compared with the control group. It was concluded that the fecal excretion of I¹³¹ after administration of labeled thyroxine is not easily altered. An increase in the bulk of the stools or an increase in biliary excretion of I¹³¹ allows an abnormally increased loss of I¹³¹ in the feces. A decrease in weight and bulk of the stools is accompanied by a decreased loss of I¹³¹. The small goiter produced in rats fed soy flour did not appear to be on the basis of excessive loss of thyroxine in feces. (auth)
- Research Organization:
- Mayo Clinic; Mayo Foundation, Rochester, Minn.
- Sponsoring Organization:
- USDOE
- NSA Number:
- NSA-15-030395
- OSTI ID:
- 4841127
- Journal Information:
- Endocrinology, Journal Name: Endocrinology Journal Issue: 4 Vol. 69; ISSN 0013-7227
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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