Biological differences in cadmium and zinc turnover

Journal Article · Thu Jun 01 00:00:00 EDT 1972 · Arch. Environ. Health; (United States)

DOI:https://doi.org/10.1080/00039896.1972.10666117· OSTI ID:6430544

Shaikh, Z A; Lucis, O J

In rat plasma, /sup 109/Cd was mainly associated with ..alpha..-globulin fraction and /sup 65/Zn was bound to ..alpha..- and ..beta..-globulins. Subcutaneously injected cadmium chloride Cd 109 and zinc chloride Zn 65 resulted in rapid clearance of /sup 109/Cd from blood plasma, as compared to /sup 65/Zn. Blood cells accumulated /sup 65/Zn more rapidly than /sup 109/Cd. Greatest uptakes of /sup 109/Cd per unit weight of tissue were by liver, kidneys, and pancreas, but that of /sup 65/Zn was by the pancreas. From all tissues, /sup 65/Zn was depleted eventually. In the first six hours after isotope dose, testis tissue concentrated more /sup 109/Cd than /sup 65/Zn. In testes, /sup 65/Zn-influx continued for 168 hours, without further /sup 1/)2)/sup 9/Cd increase. Both isotopes were excreted predominantly via intestinal tract. Fecal and urinary excretion of /sup 109/Cd and )2and/sup 5/Zn was accelerated by 2,3-dimercapto-1-propanol. Results indicate /sup 109/Cd follows metabolic pathways different from those of /sup 65/Zn. 30 references, 6 figures, 3 tables.

• Research Organization: Dalhousie Univ., Halifax, Nova Scotia
• OSTI ID: 6430544
• Journal Information: Arch. Environ. Health; (United States), Journal Name: Arch. Environ. Health; (United States) Vol. 24; ISSN AEHLA
• Country of Publication: United States
• Language: English

Related Subjects

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59 BASIC BIOLOGICAL SCIENCES
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL LOCALIZATION
BIOLOGICAL MATERIALS
BIOLOGICAL PATHWAYS
BIOLOGICAL WASTES
BLOOD
BLOOD CELLS
BLOOD CHEMISTRY
BLOOD PLASMA
BODY
BODY FLUIDS
CADMIUM
CADMIUM 109
CADMIUM CHLORIDES
CADMIUM COMPOUNDS
CADMIUM HALIDES
CADMIUM ISOTOPES
CHLORIDES
CHLORINE COMPOUNDS
CLEARANCE
COMPARATIVE EVALUATIONS
DAYS LIVING RADIOISOTOPES
DIGESTIVE SYSTEM
ELECTRON CAPTURE RADIOISOTOPES
ELEMENTS
ENDOCRINE GLANDS
ERYTHROCYTES
EVEN-ODD NUCLEI
EXCRETION
FECES
GASTROINTESTINAL TRACT
GLANDS
GLOBULINS
GLOBULINS-ALPHA
GLOBULINS-BETA
GONADS
HALIDES
HALOGEN COMPOUNDS
INJECTION
INTAKE
INTERMEDIATE MASS NUCLEI
INTESTINES
ISOTOPES
KIDNEYS
LIVER
MALE GENITALS
MAMMALS
MATERIALS
METALS
NUCLEI
ORGANIC COMPOUNDS
ORGANS
PANCREAS
PROTEINS
RADIOISOTOPES
RATS
RESPONSE MODIFYING FACTORS
RODENTS
STIMULATION
SUBCUTANEOUS INJECTION
TESTES
UPTAKE
URINE
VERTEBRATES
WASTES
YEARS LIVING RADIOISOTOPES
ZINC
ZINC 65
ZINC CHLORIDES
ZINC COMPOUNDS
ZINC HALIDES
ZINC ISOTOPES