Effects of potassium or potassium/magnesium supplementation on potassium content of body tissues and fluids in furosemide-treated rats on magnesium-deficient or magnesium-sufficient diet

Journal Article · Mon Jan 01 00:00:00 EST 1990 · Life Sciences; (USA)

DOI:https://doi.org/10.1016/0024-3205(90)90052-S· OSTI ID:6521268

Coram, W M; Kapeghian, J C; Plocinski, A F; Toledo, L M; Douglas, F L; Weiss, G B ^[1]

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1. Univ. of New Jersey, Newmark (USA)

Persistent Mg{sup 2+} deficiency may interfere with restoration of normal tissue K{sup +} levels. This study examined: (a) the effects of chronic furosemide treatment of K{sup +} of sartorius, aorta and ventricle of rats fed Mg{sup 2+}-deficient or Mg{sup 2+} sufficient diet and deionized water; (b) whether normal tissue K{sup +} is restored by oral K{sup +} or K{sup +}/Mg{sup 2+} supplementation with continued furosemide therapy. Levels of Mg{sup 2+} were also measured. Furosemide decreased K{sup +} in sartorius, aorta and ventricle by 5.5, 4.3 and 19.9 {mu}Eq/gm, respectively, in rats fed 100 ppm Mg{sup 2+} diet. Furosemide did not alter K{sup +} levels in rats fed 400 ppm Mg{sup 2+} diet. K{sup +} supplementation restored K{sup +} to normal in sartorius but the addition of Mg{sup 2+} supplementation was necessary to restore K+ levels to normal in ventricle and aorta. These data indicate that furosemide can decrease tissue K{sup +} in rats on a Mg{sup 2+}- deficient diet. This decrease can be reversed during diuretic administration by K{sup +} supplementation in sartorius, or K{sup +} plus Mg{sup 2+} supplementation in ventricle and aorta.

• OSTI ID: 6521268
• Journal Information: Life Sciences; (USA), Vol. 46:1; ISSN 0024-3205
• Country of Publication: United States
• Language: English

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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
DIURETICS
BIOLOGICAL EFFECTS
MAGNESIUM
NUTRITIONAL DEFICIENCY
POTASSIUM COMPOUNDS
BODY COMPOSITION
AORTA
DIET
RATS
ALKALI METAL COMPOUNDS
ALKALINE EARTH METALS
ANIMALS
ARTERIES
BLOOD VESSELS
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CARDIOVASCULAR SYSTEM
DRUGS
ELEMENTS
MAMMALS
METALS
ORGANS
RODENTS
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