Diesel-exhaust particulates inoculated by the intranasal route have an adjuvant activity for IgE production in mice

Journal Article · Wed Apr 01 04:00:00 EST 1987 · J. Allergy Clin. Immunol.; (United States)

DOI:https://doi.org/10.1016/S0091-6749(87)80161-6· OSTI ID:6514540

Takafuji, S; Suzuki, S; Koizumi, K; Tadokoro, K; Miyamoto, T; Ikemori, R; Muranaka, M

Our previous study indicated that the IgE antibody responses in mice immunized with intraperitoneal injection of the antigens mixed with diesel-exhaust particulates (DEP) were higher than those in the animals immunized with the antigens alone. We examined the adjuvant activity of DEP inoculated by the intranasal route, i.e., the natural entrance of DEP. In 3-week interval immunization, the IgE antibody responses in mice immunized with intranasal inoculation of ovalbumin (OA) mixed with DEP were higher than responses in the animals immunized with OA alone. DEP had an adjuvant activity for anti-OA IgE antibody production, even in a small dose such as 1 micrograms administered with a 3-week interval. Also in 1-week interval immunization, the enhancing effect of DEP on anti-OA IgE antibody production was demonstrated when mice were immunized with intranasal inoculation of OA and DEP. The possibility cannot be excluded that DEP, which are kept buoyant in the environmental atmosphere of urban districts, may exert an adjuvant activity for IgE antibody production after being inhaled into the human body and have some relation to the mechanism of the outbreak of allergic rhinitis caused by pollens in Japan.

• Research Organization: Univ. of Tokyo, Japan
• OSTI ID: 6514540
• Journal Information: J. Allergy Clin. Immunol.; (United States), Journal Name: J. Allergy Clin. Immunol.; (United States) Vol. 4; ISSN JACIB
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALLERGY
ANIMALS
ANTIBODY FORMATION
ANTIGEN-ANTIBODY REACTIONS
BIOLOGICAL EFFECTS
DIESEL FUELS
EXHAUST GASES
FLUIDS
GASEOUS WASTES
GASES
GLOBULINS
IMMUNOGLOBULINS
MAMMALS
MICE
ORGANIC COMPOUNDS
PARTICLES
PARTICULATES
PATHOLOGICAL CHANGES
PETROLEUM PRODUCTS
PROTEINS
RESPONSE MODIFYING FACTORS
RODENTS
VERTEBRATES
WASTES