Regulation of the IgE antibody response in mice. I. Long-term production of IgE anti-ovalbumin antibody in irradiated recipients. [Gamma radiation]

Journal Article · Sun Oct 01 04:00:00 EDT 1978 · J. Immunol.; (United States)

OSTI ID:6629936

Peeters, S H; Carter, B G

An adoptive cell transfer system was defined for studying the long-term IgE anti-ovalbumin (OA) response of B6D2F/sub 1/ mice. The primary IgE anti-OA response given by this strain persisted for more than 8 months and the half-life of the IgE anti-OA in circulation was 10.5 hr as measured by residual passive cutaneous anaphylaxis (PCA) in rat skin. The system described for studying cell recruitment patterns in this response involves the transfer of primed spleen cells to irradiated recipients and the production in these recipients of IgE and hemagglutinating antibody without further overt antigenic challenge. The capacity of primed spleen cells to transfer the response was detectable 10 days after immunization and increased for the next 6 weeks. After this time the ability of primed cells to transfer the response declined steadily, but was still evident 8 months after immunization of the donor animals. The transferred response itself persisted in the recipients for many months.

• Research Organization: Univ. of Manitoba, Winnipeg
• OSTI ID: 6629936
• Journal Information: J. Immunol.; (United States), Journal Name: J. Immunol.; (United States) Vol. 121:R4; ISSN JOIMA
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
ANTIBODIES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
CARBOHYDRATES
CONTROL
ELECTROMAGNETIC RADIATION
GAMMA RADIATION
GLOBULINS
GLUCOPROTEINS
IMMUNE REACTIONS
IMMUNOGLOBULINS
IONIZING RADIATIONS
MAMMALS
MICE
ORGANIC COMPOUNDS
OVALBUMIN
PROTEINS
RADIATION EFFECTS
RADIATIONS
RODENTS
SACCHARIDES
VERTEBRATES