Suppression of IgE antibody production in SJL mice. V. Effect of irradiation and adult thymectomy on the suppression of IgE antibody production in SJL mice
Journal Article
·
· Cell. Immunol.; (United States)
Anti-DNP IgE antibody production was low and transient in SJL mice which were immunized with 1 microgram DNP-Nb and 1 mg A1(OH)/sub 3/. The immunized SJL mice were irradiated (60-540 R) 1 day after challenge. A dose higher than 180 R induced enhancement of anti-DNP IgE antibody production as compared to nonirradiated control mice, suggesting the existence of irradiation-sensitive suppressor cells. Anti-DNP IgE antibody production was suppressed when immunized and irradiated SJL mice were injected with spleen cells from adult-thymectomized SJL mice. The donors of the spleen cells were thymectomized 2 or 4 months previously, and this suggests that the suppressor cells from unprimed mice are long-living T cells.
- Research Organization:
- Department of Parasitology, Jikei University School of Medicine, Tokyo, Japan
- OSTI ID:
- 5713160
- Journal Information:
- Cell. Immunol.; (United States), Journal Name: Cell. Immunol.; (United States) Vol. 79:2; ISSN CLIMB
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMAL TISSUES
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOSYNTHESIS
BODY
GLOBULINS
IMMUNOGLOBULINS
IMMUNOSUPPRESSION
LYMPHATIC SYSTEM
MAMMALS
MICE
ORGANIC COMPOUNDS
ORGANS
PROTEINS
RADIATION EFFECTS
RETICULOENDOTHELIAL SYSTEM
RODENTS
SOMATIC CELLS
SPLEEN CELLS
SYNTHESIS
THYMUS
TISSUES
VERTEBRATES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMAL TISSUES
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOSYNTHESIS
BODY
GLOBULINS
IMMUNOGLOBULINS
IMMUNOSUPPRESSION
LYMPHATIC SYSTEM
MAMMALS
MICE
ORGANIC COMPOUNDS
ORGANS
PROTEINS
RADIATION EFFECTS
RETICULOENDOTHELIAL SYSTEM
RODENTS
SOMATIC CELLS
SPLEEN CELLS
SYNTHESIS
THYMUS
TISSUES
VERTEBRATES